782-74-1

Basic information

• Product Name: 1,2-bis(2-chlorophenyl)hydrazine
• Synonyms: 1,2-bis(2-chlorophenyl)hydrazine;1,2-Bis(2-chlorphenyl)hydrazin;N,N'-Bis-(2-chloro-phenyl)-hydrazine
• CAS NO: 782-74-1
• Molecular Formula: C₁₂H₁₀Cl₂N₂
• Molecular Weight: 253.1272
• EINECS: 212-314-7
• Mol File: 782-74-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 280.8°C at 760 mmHg
• Flash Point: 123.6°C
• Appearance: /
• Density: 1.405g/cm³
• Vapor Pressure: 0.0037mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,2-bis(2-chlorophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(2-chlorophenyl)hydrazine(782-74-1)
• EPA Substance Registry System: 1,2-bis(2-chlorophenyl)hydrazine(782-74-1)

Safety Data

• Hazardous Substances Data: 782-74-1(Hazardous Substances Data)

Usage

Description

1,2-bis(2-chlorophenyl)hydrazine, a hydrazine derivative with the molecular formula C12H12Cl2N2, is a yellow crystalline solid that is insoluble in water. It is a chemical compound known for its potential applications in various industrial and research fields, including the synthesis of pharmaceuticals, agrochemicals, dyes, and pigments. Additionally, it has been studied for its potential biological activity and use in treating certain medical conditions. However, due to its toxic nature, it requires careful handling to prevent harm.

Uses

Used in Pharmaceutical Synthesis:
1,2-bis(2-chlorophenyl)hydrazine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 1,2-bis(2-chlorophenyl)hydrazine is utilized as a precursor in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Dye and Pigment Manufacturing:
1,2-bis(2-chlorophenyl)hydrazine is employed as a building block in the manufacturing of dyes and pigments, contributing to the creation of a wide range of colorants used in various industries, such as textiles, plastics, and printing inks.
Used in Research and Development:
1,2-bis(2-chlorophenyl)hydrazine is used as a research chemical for studying its potential biological activity and exploring its applications in the treatment of certain medical conditions, thereby contributing to advancements in medical science.

InChI:InChI=1/C12H10Cl2N2/c13-9-5-1-3-7-11(9)15-16-12-8-4-2-6-10(12)14/h1-8,15-16H

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Downstream Products

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Relevant articles and documents

Visible-Light-Promoted Diboron-Mediated Transfer Hydrogenation of Azobenzenes to Hydrazobenzenes

A visible-light-promoted transfer hydrogenation of azobenzenes has been developed. In the presence of B2pin2 and upon visible-light irradiation, the reactions proceeded smoothly in methanol at ambient temperature. The azobenzenes with diverse functional groups have been reduced to the corresponding hydrazobenzenes with a yield of up to 96%. Preliminary mechanistic studies indicated that the hydrogen atom comes from the solvent and the transformation is achieved through a radical pathway.

Convenient semihydrogenation of azoarenes to hydrazoarenes using H2

The high atom-economical and eco-benign nature of hydrogenation reactions make them much more superior to conventional reduction and transfer hydrogenation. Herein, a convenient and highly selective hydrogenation reaction of azoarenes using molecular hydrogen to access diverse hydrazoarenes is reported. The present catalytic method is general and operationally simple, and it operates under exceedingly mild conditions (room temperature and 1 atm of hydrogen pressure). The reusability of catalysts used in this method is also successfully demonstrated.

Synthesis of novel 1,2-diarylpyrazolidin-3-one–based compounds and their evaluation as broad spectrum antibacterial agents

There is a continuous need to develop new antibacterial agents with non-traditional mechanisms to combat the nonstop emerging resistance to most of the antibiotics used in clinical settings. We identified novel pyrazolidinone derivatives as antibacterial hits in an in-house library screening and synthesized several derivatives in order to improve the potency and increase the polarity of the discovered hit compounds. The oxime derivative 24 exhibited promising antibacterial activity against E. coli TolC, B. subtilis and S. aureus with MIC values of 4, 10 and 20 μg/mL, respectively. The new lead compound 24 was found to exhibit a weak dual inhibitory activity against both the E. coli MurA and MurB enzymes with IC50 values of 88.1 and 79.5 μM, respectively, which could partially explain its antibacterial effect. A comparison with the previously reported, structurally related pyrazolidinediones suggested that the oxime functionality at position 4 enhanced the activity against MurA and recovered the activity against the MurB enzyme. Compound 24 can serve as a lead for further development of novel and safe antibiotics with potential broad spectrum activity.