777-11-7 Usage
Description
HALOPROGIN (200 MG) is a potent antifungal agent commonly used in the treatment of various fungal infections. It is characterized by its ability to inhibit the growth and proliferation of fungi, making it a valuable pharmaceutical compound for addressing dermatophytic and monilial infections.
Uses
Used in Pharmaceutical Industry:
HALOPROGIN (200 MG) is used as a topical antifungal agent for the treatment of dermatophytic and monilial infections. It effectively targets and eliminates the fungi responsible for these infections, promoting skin health and preventing the spread of the infection.
Used in Cosmetic Industry:
HALOPROGIN (200 MG) is also used as an antibacterial agent in cosmetic products. Its ability to inhibit bacterial growth helps maintain skin cleanliness and prevent the development of acne and other skin-related issues.
Originator
Halotex,Westwood,US,1972
Indications
Haloprogin is used as an external drug for moderate dermatophyte infections (shingles),
and it is effective for superficial candida infections. Synonyms of this drug are halotex,
mycilan, micanden, and others.
Manufacturing Process
4.7 grams of 2,4,5-trichlorophenyl propargyl ether (MP 64° to 65°C) are
added to an aqueous solution of cupro-ammonium complex salt which has been prepared by warming a mixture of 4.0 grams of cuprous chloride, 11.0
grams of ammonium carbonate and 20 cc of water to 50°C. The resulting
admixture is shaken vigorously. The cuprous acetylide deposited is filtered,
washed with water and suspended in 100 cc of water, and the suspension is
mixed under agitation with a solution of 5.0 grams of iodine and 5.0 grams of
potassium iodide in 15 cc of water. The mixture is stirred for a period of 1
hour. The precipitate is filtered, washed with water and extracted with ether.
After the drying of the ethereal extract, the solvent is distilled off.
Recrystallization of the residue from n-hexane gives about 5.6 grams of 2,4,5-
trichlorophenyi iodopropargyl ether, MP 114° to 115°C.
Therapeutic Function
Antibacterial
Synthesis
Haloprogin, 3-iodo-2-propinyl-2,4,5-trichlorophenyl ether (35.4.11), is synthesized by an iodide substitution using a mixture of iodine and potassium iodide and a
cupric derivative of 2,4,5-trichlorophenylpropargyl ether (35.4.10), which is synthesized
by a standard method from propargyl bromide and 2,4,5-trichlorophenol in the presence of
sodium hydroxide.
Check Digit Verification of cas no
The CAS Registry Mumber 777-11-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 7 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 777-11:
(5*7)+(4*7)+(3*7)+(2*1)+(1*1)=87
87 % 10 = 7
So 777-11-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2
