773838-08-7 Usage
Description
3-[(4-HYDROXYBENZOYL)AMINO]PROPANOIC ACID, also known as N-(4-Hydroxybenzoyl)-β-alanine, is a metabolite of β-Alanine, a naturally occurring beta amino acid. It features a unique structure with a hydroxybenzoyl group attached to the β-alanine backbone, which may confer specific biological properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
3-[(4-HYDROXYBENZOYL)AMINO]PROPANOIC ACID is used as an intermediate in the synthesis of antibiotics, specifically for the preparation of closthioamide. Its unique structure likely contributes to the antibiotic's activity against certain bacterial strains, making it a valuable component in the development of new antimicrobial agents to combat drug-resistant infections.
Given the limited information provided, the primary application of 3-[(4-HYDROXYBENZOYL)AMINO]PROPANOIC ACID appears to be in the pharmaceutical industry for antibiotic development. Further research and exploration may reveal additional uses in other industries or applications, such as potential roles in drug delivery systems, therapeutic agents, or as building blocks for other bioactive compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 773838-08-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,7,3,8,3 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 773838-08:
(8*7)+(7*7)+(6*3)+(5*8)+(4*3)+(3*8)+(2*0)+(1*8)=207
207 % 10 = 7
So 773838-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO4/c12-8-3-1-7(2-4-8)10(15)11-6-5-9(13)14/h1-4,12H,5-6H2,(H,11,15)(H,13,14)
773838-08-7Relevant articles and documents
Reconstitution of Iterative Thioamidation in Closthioamide Biosynthesis Reveals Tailoring Strategy for Nonribosomal Peptide Backbones
Dunbar, Kyle L.,Dell, Maria,Molloy, Evelyn M.,Kloss, Florian,Hertweck, Christian
, p. 13014 - 13018 (2019)
Thioamide-containing nonribosomal peptides (NRPs) are exceedingly rare. Recently the biosynthetic gene cluster for the thioamidated NRP antibiotic closthioamide (CTA) was reported, however, the enzyme responsible for and the timing of thioamide formation remained enigmatic. Here, genome editing, biochemical assays, and mutational studies are used to demonstrate that an Fe-S cluster containing member of the adenine nucleotide α-hydrolase protein superfamily (CtaC) is responsible for sulfur incorporation during CTA biosynthesis. However, unlike all previously characterized members, CtaC functions in a thiotemplated manner. In addition to prompting a revision of the CTA biosynthetic pathway, the reconstitution of CtaC provides the first example of a NRP thioamide synthetase. Finally, CtaC is used as a bioinformatic handle to demonstrate that thioamidated NRP biosynthetic gene clusters are more widespread than previously appreciated.
CLOSTHIOAMIDES
-
, (2011/05/11)
This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.
