7726-11-6Relevant articles and documents
Kinetics of the Reactions of the Formyl Radical with Oxygen, Nitrogen Dioxide, Chlorine, and Bromine
Timonen, Raimo S.,Ratajczak, Emil,Gutman, David
, p. 651 - 655 (1988)
The gas-phase kinetics of the reactions of HCO with four molecules (O2, NO2, Cl2, and Br2) have been studied as a function of temperature in a tubular reactor coupled to a photoionization mass spectrometer.Rate constants for each reaction were determined at a minimum of five temperatures to obtain Arrhenius parameters (k=A exp(-Ea/RT)).The results obtained are as follows (the numbers in the brackets are log A/(cm3 molecule-1 s1-), Ea/(kJ mol-1), and the temperature ranges covered): HCO+O2 ; HCO+NO2 ; HCO+Cl2 ; HCO+Br2 .The reactivity of HCO was found to be between that of CH3 and C2H5 in the reactions of these radicals with Cl2 and Br2, which is consistent with proposed correlations of reactivity in exothermic reactions based on free-radical ionization potentials.
Kinetics of the brominated alkyl radical (CHBr2, CH 3CHBr) reactions with NO2 in the temperature range 250-480 K
Rissanen, Matti P.,Eskola, Arkke J.,Timonen, Raimo S.
, p. 767 - 777 (2013/01/15)
The gas-phase kinetics of CHBr2 + NO2 and CH 3CHBr + NO2 reactions have been studied in direct time resolved measurements using a tubular flow reactor coupled to a photoionization mass spectrometer. The radicals were generated by pulsed laser photolysis of bromoform and 1,1-dibromoethane at 248 nm. The subsequent decays of the radical concentrations were monitored as a function of [NO2] under pseudo-first-order conditions. The rate coefficients of both reactions are independent of bath gas (He) pressure and display negative temperature dependence under the conditions of 2-6 Torr pressure (He) and 250-480 K. The obtained bimolecular rate coefficients are k(CHBr2 + NO2) = (9.8 ± 0.4) × 10-12 (T/300 K) -1.65 ± 0.18 cm3 s-1 (288-483 K) and k(CH3CHBr + NO2) = (2.27 ± 0.06) × 10 -11 (T/300 K)-1.28 ± 0.11 cm3 s -1 (250-483 K), with the uncertainties given as one standard error. Estimated overall uncertainties in the measured bimolecular reaction rate coefficients are ±25%. The reaction products identified were CBr 2O for the CHBr2 + NO2 reaction and CHBrO and CH3CHO with minor amounts of CH3 for the CH 3CHBr + NO2 reaction, respectively. 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 767-777, 2012 Copyright
Hepatitis C inhibitor tri-peptides
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, (2008/06/13)
Disclosed herein are compounds of formula (1): wherein R1is hydroxy or NHSO2R1Awherein R1Ais (C1-8)alkyl, (C3-7)cycloalkyl or {(C1-6)alkyl-(C3-7)cycloalkyl}, which are all optionally substituted from 1 to 3 times with halo, cyano, nitro, O—(C1-6)alkyl, amido, amino or phenyl, or R1Ais C6or C10aryl which is optionally substituted from 1 to 3 times with halo, cyano, nitro, (C1-6)alkyl, O—(C1-6) alkyl, amido, amino or phenyl; R2is (C4-6)cycloalkyl; R3is t-butyl or (C5-6) cycloalkyl and R4is (C4-6)cycloalkyl; or a pharmaceutically acceptable salt thereof. The compounds are useful as inhibitors of HCV NS3 protease.
Carboxamide diazepin derivatives, preparation method, use as medicines, pharmaceutical compositions and use thereof
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, (2008/06/13)
The invention concerns products of formula (I) wherein: R1 represents in particular —C(O)—R5, —SO2—R5 or —C(O)—NR6R5, R2 and R7 are such that either R7 represents a hydrogen atom and R2 is such that the group (a) represents the radical of a natural or non-natural amino acid, or R2 and R7 form together a cycle with the nitrogen and carbon atom whereto they are bound, R3 represents in particular the radical —CH═N2 or —CH2-L—R4, R4 represents in particular a linear or branched alkyl radical, and their additive salts with mineral or organic acids or with mineral or organic bases of said products of formula (I). The invention also concerns the method for preparing said products and their use as medicines.
