7724-48-3

Basic information

• Product Name: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole
• Synonyms: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole;1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-(7CI,8CI,9CI);1H-Pyrrolo[1,2-a]benzimidazole,2,3-dihydro-;2-a]benzimidazole, 2,3-dihydro-1H-Pyrrolo[1;2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazole
• CAS NO: 7724-48-3
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.1998
• EINECS: 231-770-8
• Product Categories: BENZIMIDAZOLE
• Mol File: 7724-48-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 115 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 341.9 °C at 760 mmHg
• Flash Point: 160.6 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.705
• PKA: 5.87±0.20(Predicted)
• CAS DataBase Reference: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole(7724-48-3)
• EPA Substance Registry System: 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole(7724-48-3)

Safety Data

• Hazardous Substances Data: 7724-48-3(Hazardous Substances Data)

Usage

Description

2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is a heterocyclic compound characterized by a fused pyrrole and benzimidazole ring system. It is recognized for its potential pharmacological activities and is currently under investigation for its use in treating various diseases. This unique structure and its properties render it a valuable intermediate in both organic synthesis and medicinal chemistry. Moreover, it has emerged as a promising lead compound in drug development due to its diverse biological activities. In essence, 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is an important chemical with significant potential applications in pharmaceutical research and drug discovery.

Uses

Used in Pharmaceutical Research:
2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a key component in the development of new drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is utilized as an intermediate. Its properties make it instrumental in the synthesis of compounds with potential therapeutic applications.
Used in Drug Development:
2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole is used as a potential lead compound in drug development. Its diverse biological activities make it a promising candidate for further research and potential inclusion in new medications.
Used in Organic Synthesis:
This chemical is also used in organic synthesis, where its fused ring system contributes to the creation of complex organic compounds for various applications.

InChI:InChI=1/C10H10N2/c1-2-5-9-8(4-1)11-10-6-3-7-12(9)10/h1-2,4-5H,3,6-7H2

Upstream product

• 51-17-2 benzoimidazole 
• 109-70-6 1.3-chlorobromopropane 
• 95-54-5 1,2-diamino-benzene 
• 201230-82-2 carbon monoxide 
• 55899-43-9 N-allyl-1,2-phenylenediamine 
• 135347-86-3 (3-Fluoro-phenyl)-pyrrolidin-(2Z)-ylidene-amine 
• 96-48-0 4-butanolide 
• 14453-65-7 1-(2-aminophenyl)pyrrolidin-2-one 
• 615-43-0 2-iodophenylamine 
• 615-36-1 2-bromoaniline 
• 95-51-2 o-chloroaniline 
• 348-54-9 2-Fluoroaniline 
• 123-75-1 pyrrolidine 
• 586-96-9 Nitrosobenzene 

Downstream Products

• 21627-58-7 2-(pyrrolidin-1-yl)-phenylamine 
• 39161-58-5 1,2,3,4,5,6-hexahydro-benzo[b][1,4]diazocine 

Relevant articles and documents

Electrochemical Synthesis of Benzo[ d]imidazole via Intramolecular C(sp3)-H Amination

An electrochemical dehydrogenative amination for the synthesis of benzimidazoles was developed. This electrosynthesis method could address the limitations of the C(sp3)-H intramolecular amination synthesis reaction and provide novel access to obtain 1,2-disubstituted benzimidazoles without transition metals and oxidants. Under undivided electrolytic conditions, various benzimidazole derivatives could be synthesized, exhibiting functional group tolerance.

Synthesis of rutaecarpine alkaloids: Via an electrochemical cross dehydrogenation coupling reaction

Substrates are directly oxidized at the anode without using any metal catalyst and oxidant to obtain a series of nitrogen heterocyclic compounds, including benzimidazoles and quinolinones. These compounds are highly tolerant to various functional groups and heterocycle-containing substrates. In addition, natural alkaloids, such as rutaecarpine and deoxyvasicinone, can be synthesized by this method.

BENZIMIDAZOLE COMPOUND AND SYNTHESIS METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a novel benzimidazole compound having tetracyclic condensed ring and a synthesis method thereof. SOLUTION: A benzimidazole compound is represented by the formula (I). A method for synthesizing the benzimidazole compound represented by the formula (I) includes the step of reacting ortho-phenylene diamine and a lactone compound and further reacting the resulting benzimidazole compound with the lactone compound. In the formula, R1 and R4 are each independently H, a methyl group or an ethyl group excluding that two of R4 are ethyl groups or methyl groups at same time, R2 and R3 are each independently H or a methyl group, m and n are integers of 1 to 2 and n is 1 when m is 2. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT