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CAS

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76648-01-6

Cefbuperazone sodium, also known as TOMIPORAN or KEIPERAZON, is a β-lactamase resistant, third-generation cephalosporin antibiotic. It is characterized by its resistance to β-lactamase enzymes, which are produced by many bacteria to inactivate commonly used penicillins and cephalosporins. This resistance makes Cefbuperazone sodium effective against a broad range of bacteria, including those that have developed resistance to other antibiotics. Additionally, it has a serum half-life of approximately 1.5 hours, which allows for effective and sustained therapeutic action.

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  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R,3S)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-

    Cas No: 76648-01-6

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  • Hangzhou J&H Chemical Co., Ltd.
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  • 76648-01-6 Structure

  • Basic information

    1. Product Name: Cefbuperazone sodium
    2. Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R,3S)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, (6R,7S)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6R-[6α,7α,7(2R*,3S*)]]-;T 1982;Cefbuperazone sodium;Sodium (6R,7S)-7-[[(2R,3S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-3-hydroxybutanoyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(2-((2,3-dioxo-4-ethyl-1-piperazinyl)formamido)-3-hydroxybutyramido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, monosodium salt, (6R-(6-alpha,7-alpha,7(2R*,3S*)))-;Cefbuperazone Acid
    3. CAS NO:76648-01-6
    4. Molecular Formula: C22H28N9NaO9S2
    5. Molecular Weight: 649.63
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 76648-01-6.mol
    9. Article Data: 0

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Cefbuperazone sodium(CAS DataBase Reference)
    10. NIST Chemistry Reference: Cefbuperazone sodium(76648-01-6)
    11. EPA Substance Registry System: Cefbuperazone sodium(76648-01-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 76648-01-6(Hazardous Substances Data)

76648-01-6 Usage

Uses

Used in Pharmaceutical Industry:
Cefbuperazone sodium is used as an antibiotic for the treatment of various bacterial infections. Its resistance to β-lactamase enzymes allows it to be effective against a wide range of bacteria, including those that have developed resistance to other antibiotics. This makes it a valuable tool in the treatment of infections caused by both Gram-positive and Gram-negative bacteria.
Used in Hospital Settings:
In hospital settings, Cefbuperazone sodium is used to treat serious bacterial infections, particularly those that are resistant to other commonly used antibiotics. Its effectiveness against a broad spectrum of bacteria makes it a crucial component in the management of infections in patients with compromised immune systems or those who have been exposed to antibiotic-resistant bacteria.
Used in Research and Development:
Cefbuperazone sodium is also used in research and development for the study of antibiotic resistance and the development of new antimicrobial agents. Its unique properties and effectiveness against β-lactamase producing bacteria make it an important subject for research aimed at understanding the mechanisms of antibiotic resistance and developing new strategies to combat it.

Originator

Topama (Japan)

Check Digit Verification of cas no

The CAS Registry Mumber 76648-01-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,6,4 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 76648-01:
(7*7)+(6*6)+(5*6)+(4*4)+(3*8)+(2*0)+(1*1)=156
156 % 10 = 6
So 76648-01-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H29N9O9S2.Na/c1-5-29-6-7-30(16(35)15(29)34)20(39)23-12(10(2)32)14(33)24-22(40-4)18(38)31-13(17(36)37)11(8-41-19(22)31)9-42-21-25-26-27-28(21)3;/h10,12,19,32H,5-9H2,1-4H3,(H,23,39)(H,24,33)(H,36,37);/q;+1/p-1/t10-,12+,19+,22-;/m0./s1

76648-01-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium,(6R,7S)-7-[[(2R,3S)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-3-hydroxybutanoyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76648-01-6 SDS

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