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76455-48-6

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  • 4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alp

    Cas No: 76455-48-6

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  • 10000 Metric Ton/Month

  • Henan Wentao Chemical Product Co., Ltd.
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  • 4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alp

    Cas No: 76455-48-6

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  • 1 Kilogram

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  • Shandong Hanjiang Chemical Co., Ltd.
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  • 4-Benzoxazolecarboxylic acid, 6-bromo-5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alp

    Cas No: 76455-48-6

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  • 10 Gram

  • 500 Kilogram/Month

  • Zibo Hangyu Biotechnology Development Co., Ltd
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  • 76455-48-6 Structure

  • Basic information

    1. Product Name: 4-BROMO-A23187
    2. Synonyms: ANTIBIOTIC A-23187, 4-BROMO;CALCIMYCIN, 4-BROMO;4-BROMO-A23187;4-BROMO-ANTIBIOTIC;4-BROMO-ANTIBIOTIC A23187;4-BROMOCALCIMYCIN;4-BROMOCALCIMYCIN A23187;4-BROMO-CALCIUM IONOPHORE A23187
    3. CAS NO:76455-48-6
    4. Molecular Formula: C29H36BrN3O6
    5. Molecular Weight: 602.52
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 76455-48-6.mol
    9. Article Data: 0

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 735.4oC at 760 mmHg
    3. Flash Point: 398.5oC
    4. Appearance: yellow/powder
    5. Density: 1.43g/cm3
    6. Vapor Pressure: 1.05E-22mmHg at 25°C
    7. Refractive Index: 1.628
    8. Storage Temp.: 2-8°C
    9. Solubility: ethanol: 20 mg/mL
    10. CAS DataBase Reference: 4-BROMO-A23187(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-BROMO-A23187(76455-48-6)
    12. EPA Substance Registry System: 4-BROMO-A23187(76455-48-6)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 20/21/22-36/37/38
    3. Safety Statements: 26-36/37/39-36/37
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 76455-48-6(Hazardous Substances Data)

76455-48-6 Usage

Description

4-BROMO-A23187, also known as 4-Bromo-calcium Ionophore A23187, is a chemical compound that functions as an ionophore. It selectively transports Zn2+ and Mn2+ ions over Ca2+ ions, making it a valuable tool in various research applications.

Uses

Used in Biological Research:
4-BROMO-A23187 is used as a calcium mobilizer for the activation of Ca2+/calmodulin kinase II (CaMKII) in the HeLa cell line. This application aids researchers in studying the role of calcium signaling in cellular processes.
Used in Cellular Studies:
In VSC 4.1 cells, 4-BROMO-A23187 is utilized as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates. This helps scientists understand the impact of calcium ions on protein aggregation and related cellular functions.
Used in Chemical Research:
4-BROMO-A23187 is used as an ionophore that selectively transports Zn2+ and Mn2+ ions over Ca2+ ions. This selective transport property is valuable for studying the effects of different metal ions on various chemical and biological processes.

Biochem/physiol Actions

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.

Check Digit Verification of cas no

The CAS Registry Mumber 76455-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,4,5 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 76455-48:
(7*7)+(6*6)+(5*4)+(4*5)+(3*5)+(2*4)+(1*8)=156
156 % 10 = 6
So 76455-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29?/m1/s1

76455-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-BROMO-A23187

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76455-48-6 SDS

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