76455-48-6 Usage
Description
4-BROMO-A23187, also known as 4-Bromo-calcium Ionophore A23187, is a chemical compound that functions as an ionophore. It selectively transports Zn2+ and Mn2+ ions over Ca2+ ions, making it a valuable tool in various research applications.
Uses
Used in Biological Research:
4-BROMO-A23187 is used as a calcium mobilizer for the activation of Ca2+/calmodulin kinase II (CaMKII) in the HeLa cell line. This application aids researchers in studying the role of calcium signaling in cellular processes.
Used in Cellular Studies:
In VSC 4.1 cells, 4-BROMO-A23187 is utilized as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates. This helps scientists understand the impact of calcium ions on protein aggregation and related cellular functions.
Used in Chemical Research:
4-BROMO-A23187 is used as an ionophore that selectively transports Zn2+ and Mn2+ ions over Ca2+ ions. This selective transport property is valuable for studying the effects of different metal ions on various chemical and biological processes.
Biochem/physiol Actions
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.
Check Digit Verification of cas no
The CAS Registry Mumber 76455-48-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,4,5 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 76455-48:
(7*7)+(6*6)+(5*4)+(4*5)+(3*5)+(2*4)+(1*8)=156
156 % 10 = 6
So 76455-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29?/m1/s1
