756-13-8

Basic information

• Product Name: PERFLUORO(2-METHYL-3-PENTANONE)
• Synonyms: HEPTAFLUOROISOPROPYL PENTAFLUOROETHYL KETONE;PERFLUORO(2-METHYL-3-PENTANONE);1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)-3-Pentanone;Perfluoro(2-methyl-3-pentanone)98%;3-Pentone,1,1,1,2,2,4,5,5,5,-nonafluoro-4-(trifluoromethyl)-;1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoroMethyl)pentan-3-one;Heptafluoroisopropyl pentafluoroethyl ketone, 1,1,1,2,2,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pentan-3-one;Perfluoro(2-methylpentan-3-one) 98%
• CAS NO: 756-13-8
• Molecular Formula: C₆F₁₂O
• Molecular Weight: 316.04
• EINECS: 436-710-6
• Mol File: 756-13-8.mol

Chemical Properties

• Melting Point: -108°C
• Boiling Point: 49°C
• Flash Point: 9.1°C
• Appearance: /
• Density: 1,6 g/cm3
• Vapor Pressure: 196mmHg at 25°C
• Refractive Index: 1.264
• Water Solubility: 24-332.6mg/L at 25℃
• CAS DataBase Reference: PERFLUORO(2-METHYL-3-PENTANONE)(CAS DataBase Reference)
• NIST Chemistry Reference: PERFLUORO(2-METHYL-3-PENTANONE)(756-13-8)
• EPA Substance Registry System: PERFLUORO(2-METHYL-3-PENTANONE)(756-13-8)

Safety Data

• Hazard Codes: Xi
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 756-13-8(Hazardous Substances Data)

Usage

Uses

Used in Magnesium Industry:
Perfluoro(2-methyl-3-pentanone) is used as a flame retardant in the magnesium industry to protect molten magnesium from burning. Its outstanding flame retardant effect ensures the safety of the magnesium production process and prevents any potential hazards.
Used in Fire Extinguishing Agents:
Perfluoro(2-methyl-3-pentanone) is also used in fire extinguishing agents due to its effective flame retardant properties. It helps extinguish fires quickly and efficiently without causing any harm to the environment. This makes it an ideal choice for environmentally friendly fire suppression systems.

Preparation

158 g of perfluoro-2,3-epoxy-2-methyl pentane, 2.9 g of potassium fluoride, 6 g of sulfolane and 100 mL of diglyme are added into a 500 mL three-neck flask equipped with a reflux condensing tube and a mechanical stirring device, respectively. The temperature is raised to be 30 °C after stir starts. After 3 hours of reaction, the reaction product of Perfluoro(2-methyl-3-pentanone) is analyzed by gas chromatography.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C6F12O/c7-2(4(10,11)12,5(13,14)15)1(19)3(8,9)6(16,17)18

Synthetic route

perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With iron(III) trifluoride; 18-crown-6 ether In acetonitrile at 90℃; for 10h; Autoclave;	98.2%
With activated carbon BAU-A-2 supported 20 wtpercent CsF In neat (no solvent) at 95℃; under 1875.19 Torr;
at 160℃; under 750.075 Torr; for 10h; Gas phase;

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
In diethylene glycol at 60℃; for 2h; Temperature; Reagent/catalyst; Autoclave;	97.8%
With triethylamine In acetonitrile at 30℃; for 0.166667h; Temperature; Reagent/catalyst; Solvent; Time;	97.1%
With sodium fluoride In 1,2-dimethoxyethane at 20℃; for 9h;	94%

polytetrafluoroethylene (116-14-3) + perfluoroisobutyryl fluoride (677-84-9) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With iron(III) trifluoride; 18-crown-6 ether In acetonitrile at 90℃; for 10h; Autoclave;	96.8%
at 160℃; under 750.075 Torr; for 10h; Gas phase;

trans-2,3-epoxyperfluoro-4-methylpentane (788-50-1, 73041-04-0, 117642-62-3) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In 1,2-dimethoxyethane at 50℃; for 9h;	92%

2,3-bi(fluorosulfato)perfluoro-4-methylpentane (75677-98-4) → pentafluoropropionic acid (422-64-0) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 20℃; for 4h;	A 76% B 16%

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoro(2-propoxypropionyl) fluoride (2062-98-8, 125037-08-3) + perfluoro-2-methyl-2-pentene (359-72-8) + perfluoro-2-methylpentan-3-one (756-13-8) + perfluoro-4-methylpent-1-ene (287101-12-6)

Conditions	Yield
With potassium fluoride In diethylene glycol dimethyl ether	A 9.7% B n/a C 63.5% D 18%

perfluoro-2-methylpent-2-ene (1584-03-8) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / sodium hypochlorite / H2O; acetonitrile 2: 94 percent / NaF / 1,2-dimethoxy-ethane / 9 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hypochlorite; urea / acetonitrile; water / 3 h / 20 °C 2: potassium fluoride; 18-crown-6 ether / diethylene glycol dimethyl ether / 3 h / 30 °C View Scheme

trans-perfluoro-(4-methyl-2-pentene) (3709-71-5) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / sodium hypochlorite / H2O; acetonitrile 2: antimony pentafluoride / 2.5 h / 250 °C View Scheme
Multi-step reaction with 2 steps 1: 70 percent / sodium hypochlorite / H2O; acetonitrile 2: 92 percent / CsF / 1,2-dimethoxy-ethane / 9 h / 50 °C View Scheme

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Stage #1: Hexafluoropropene oxide With potassium fluoride In diethylene glycol dimethyl ether for 2h; Heating; Stage #2: perfluoropropylene In diethylene glycol dimethyl ether; acetonitrile at 65 - 80℃; under 5250.53 Torr; for 2h;
at 160℃; under 750.075 Torr; for 10h; Gas phase;

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoropropanoyl fluoride (422-61-7) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With activated carbon BAU-A-2 supported 20 wtpercent CsF In neat (no solvent) at 130℃; Reagent/catalyst; Temperature;

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoro(2-propoxypropionyl) fluoride (2062-98-8, 125037-08-3) + perfluoropropanoyl fluoride (422-61-7) + perfluoro-2-methylpentan-3-one (756-13-8) + perfluoro-4-methylpent-1-ene (287101-12-6)

Conditions	Yield
With activated carbon BAU In neat (no solvent) at 130℃; Reagent/catalyst; Temperature;

perfluoro-4-methyl-2-pentene (2070-70-4) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: sulfolane; cesium fluoride / diethylene glycol dimethyl ether / 0.5 h / 70 °C 2: sodium hypochlorite; urea / acetonitrile; water / 3 h / 20 °C 3: potassium fluoride; 18-crown-6 ether / diethylene glycol dimethyl ether / 3 h / 30 °C View Scheme
Multi-step reaction with 3 steps 1: benzyltriethylammonium bromide; potassium fluoride / acetonitrile / 4 h 2: sodium hypochlorite / diethylene glycol dimethyl ether / 4 h 3: Aliquat 336 / diethylene glycol dimethyl ether / 10 h View Scheme

perfluoro-2-methylpentan-3-one (756-13-8) → perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7)

Conditions	Yield
With cesium fluoride at 250℃; for 2h; Product distribution;	A 68% B n/a

perfluoro-2-methylpentan-3-one (756-13-8) → 3-hydroperfluoro-2-methyl-3-pentanol (87383-00-4)

Conditions	Yield
Stage #1: perfluoro-2-methylpentan-3-one With polyethylsiloxane; tetrabutoxytitanium at 100℃; Stage #2: With sodium hydroxide In tetrahydrofuran Heating;	42%
With sodium tetrahydroborate In 1,4-dioxane for 1h;

Vinylidene fluoride (75-38-7) + perfluoro-2-methylpentan-3-one (756-13-8) → 1-<2-Trifluormethyl-perfluorpentyl-(3)-oxy>-1,1-difluor-2-brom-aethan (18329-56-1)

Conditions	Yield
(i) CsF, MeCN, (ii) /BRN= 1733321/, Br2; Multistep reaction;

perfluoro-2-methylpentan-3-one (756-13-8) → 1,1,1,2,3,3,3-Heptafluoropropane (431-89-0) + pentafluoropropionic acid (422-64-0)

Conditions	Yield
With sodium hydroxide In water Product distribution;	A 92 % Chromat. B 85 % Chromat.

perfluoro-2-methylpentan-3-one (756-13-8) + dimethyl sulfate (77-78-1) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With potassium fluoride In diethylene glycol dimethyl ether at 45℃;

pyrrolidine (123-75-1) + perfluoro-2-methylpentan-3-one (756-13-8) → N-tetramethyleneperfluoropropanamide (686720-34-3) + 1,1,1,2,3,3,3-Heptafluoropropane (431-89-0) + N-butyl pentafluoropropionamide (309-24-0)

Conditions	Yield
With freon 11

perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With iron(III) trifluoride; 18-crown-6 ether In acetonitrile at 90℃; for 10h; Autoclave;	98.2%
With activated carbon BAU-A-2 supported 20 wtpercent CsF In neat (no solvent) at 95℃; under 1875.19 Torr;
at 160℃; under 750.075 Torr; for 10h; Gas phase;

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
In diethylene glycol at 60℃; for 2h; Temperature; Reagent/catalyst; Autoclave;	97.8%
With triethylamine In acetonitrile at 30℃; for 0.166667h; Temperature; Reagent/catalyst; Solvent; Time;	97.1%
With sodium fluoride In 1,2-dimethoxyethane at 20℃; for 9h;	94%

polytetrafluoroethylene (116-14-3) + perfluoroisobutyryl fluoride (677-84-9) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With iron(III) trifluoride; 18-crown-6 ether In acetonitrile at 90℃; for 10h; Autoclave;	96.8%
at 160℃; under 750.075 Torr; for 10h; Gas phase;

trans-2,3-epoxyperfluoro-4-methylpentane (788-50-1, 73041-04-0, 117642-62-3) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In 1,2-dimethoxyethane at 50℃; for 9h;	92%

2,3-bi(fluorosulfato)perfluoro-4-methylpentane (75677-98-4) → pentafluoropropionic acid (422-64-0) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 20℃; for 4h;	A 76% B 16%

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoro(2-propoxypropionyl) fluoride (2062-98-8, 125037-08-3) + perfluoro-2-methyl-2-pentene (359-72-8) + perfluoro-2-methylpentan-3-one (756-13-8) + perfluoro-4-methylpent-1-ene (287101-12-6)

Conditions	Yield
With potassium fluoride In diethylene glycol dimethyl ether	A 9.7% B n/a C 63.5% D 18%

1,1,1,4,5,5,5-heptafluoro-3-(pentafluoroethyl)-2,4-bis(trifluoromethyl)pent-2-ene (30320-26-4) → perfluoro-2-methylpentan-3-one (756-13-8) + 2,2-bis(fluorosulfonyloxy)perfluoropropane

Conditions	Yield
With bis(fluorosulfuryl) peroxide at 80℃; for 192h;	A 61% B 49%
With bis(fluorosulfuryl) peroxide at 70 - 80℃;

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) → perfluoro-2-methylpentan-3-one (756-13-8) + 2-chloroundecafluoro-2-methyl-3-pentanone (83714-48-1)

Conditions	Yield
With sodium chloride In diethylene glycol dimethyl ether for 20h; Heating;	A 35% B 55.8%

2-chloroundecafluoro-2-methyl-3-pentanone (83714-48-1) → perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In diethylene glycol dimethyl ether for 1h; Product distribution; Heating;	A n/a B n/a C 38%

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) + urea (57-13-6) → perfluoro-2-methylpentan-3-one (756-13-8) + 1-(2,2,3,3,3-pentafluoropropionyl)-3-(2,2,2-trifluoro-1-trifluoromethylethyl)urea (1315483-13-6)

Conditions	Yield
In acetonitrile for 17h; Heating; Sealed tube;	A n/a B 25%

perfluoro(4-methyl-2-pentene) oxide (788-50-1) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In diethylene glycol dimethyl ether

perfluoro(4-methyl-2-pentene) oxide (788-50-1) → perfluoro(2,4-dimethyloxolane) (68970-43-4) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With antimony pentafluoride at 200℃; for 10h; Yield given. Yields of byproduct given;

2,3-bis(fluorosulfato)perfluoro-(2-methylpentane) (132182-90-2) → hexafluoroacetone hydrate (677-71-4) + pentafluoropropionic acid (422-64-0) + perfluoro-2-methylpentan-3-one (756-13-8) + 1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0)

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 10℃; for 1h; Yield given;	A n/a B n/a C 1.5 g D 0.3 g
With cesium fluoride In N,N-dimethyl-formamide at 10℃; for 1h;	A n/a B n/a C 1.5 g D 0.3 g

trans-2,3-epoxyperfluoro-4-methylpentane (788-50-1, 73041-04-0, 117642-62-3) → perfluoro(4-methyl-2-pentanone) (73041-05-1) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With antimony pentafluoride at 250℃; for 2.5h; Yield given. Yields of byproduct given;

2,3-epoxyperfluoro-3-isopropyl-4-methylpentane (103697-21-8) → perfluoropropylene (116-15-4) + perfluoro-2-methylpent-2-ene (1584-03-8) + 1,1,1,2,3,5,5,6,6,7,7,7-dodecafluoro-2,4-bis(trifluoromethyl)hept-3-ene (30320-29-7) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With cesium fluoride In diethylene glycol dimethyl ether for 2h; Heating; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;	A 0.8 g B n/a C n/a D n/a
With cesium fluoride In diethylene glycol dimethyl ether for 2h; Heating; Yield given. Further byproducts given. Title compound not separated from byproducts;	A 0.8 g B n/a C n/a D n/a

perfluoro-2-methylpent-2-ene (1584-03-8) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / sodium hypochlorite / H2O; acetonitrile 2: 94 percent / NaF / 1,2-dimethoxy-ethane / 9 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hypochlorite; urea / acetonitrile; water / 3 h / 20 °C 2: potassium fluoride; 18-crown-6 ether / diethylene glycol dimethyl ether / 3 h / 30 °C View Scheme

trans-perfluoro-(4-methyl-2-pentene) (3709-71-5) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / sodium hypochlorite / H2O; acetonitrile 2: antimony pentafluoride / 2.5 h / 250 °C View Scheme
Multi-step reaction with 2 steps 1: 70 percent / sodium hypochlorite / H2O; acetonitrile 2: 92 percent / CsF / 1,2-dimethoxy-ethane / 9 h / 50 °C View Scheme

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Stage #1: Hexafluoropropene oxide With potassium fluoride In diethylene glycol dimethyl ether for 2h; Heating; Stage #2: perfluoropropylene In diethylene glycol dimethyl ether; acetonitrile at 65 - 80℃; under 5250.53 Torr; for 2h;
at 160℃; under 750.075 Torr; for 10h; Gas phase;

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoropropanoyl fluoride (422-61-7) + perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
With activated carbon BAU-A-2 supported 20 wtpercent CsF In neat (no solvent) at 130℃; Reagent/catalyst; Temperature;

Hexafluoropropene oxide (428-59-1) + perfluoropropylene (116-15-4) → perfluoro(2-propoxypropionyl) fluoride (2062-98-8, 125037-08-3) + perfluoropropanoyl fluoride (422-61-7) + perfluoro-2-methylpentan-3-one (756-13-8) + perfluoro-4-methylpent-1-ene (287101-12-6)

Conditions	Yield
With activated carbon BAU In neat (no solvent) at 130℃; Reagent/catalyst; Temperature;

perfluoro-4-methyl-2-pentene (2070-70-4) → perfluoro-2-methylpentan-3-one (756-13-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: sulfolane; cesium fluoride / diethylene glycol dimethyl ether / 0.5 h / 70 °C 2: sodium hypochlorite; urea / acetonitrile; water / 3 h / 20 °C 3: potassium fluoride; 18-crown-6 ether / diethylene glycol dimethyl ether / 3 h / 30 °C View Scheme
Multi-step reaction with 3 steps 1: benzyltriethylammonium bromide; potassium fluoride / acetonitrile / 4 h 2: sodium hypochlorite / diethylene glycol dimethyl ether / 4 h 3: Aliquat 336 / diethylene glycol dimethyl ether / 10 h View Scheme

perfluoro-2-methylpentan-3-one (756-13-8) → perfluoropropylene (116-15-4) + perfluoropropanoyl fluoride (422-61-7)

Conditions	Yield
With cesium fluoride at 250℃; for 2h; Product distribution;	A 68% B n/a

perfluoro-2-methylpentan-3-one (756-13-8) → 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentanol (87383-00-4)

Conditions	Yield
Stage #1: perfluoro-2-methylpentan-3-one With polyethylsiloxane; tetrabutoxytitanium at 100℃; Stage #2: With sodium hydroxide In tetrahydrofuran Heating;	42%
With sodium tetrahydroborate In 1,4-dioxane for 1h;
With sodium tetrahydroborate at 0℃; for 1.5h;

Vinylidene fluoride (75-38-7) + perfluoro-2-methylpentan-3-one (756-13-8) → 1-<2-Trifluormethyl-perfluorpentyl-(3)-oxy>-1,1-difluor-2-brom-aethan (18329-56-1)

Conditions	Yield
(i) CsF, MeCN, (ii) /BRN= 1733321/, Br2; Multistep reaction;

perfluoro-2-methylpentan-3-one (756-13-8) → 1,1,1,2,3,3,3-Heptafluoropropane (431-89-0) + pentafluoropropionic acid (422-64-0)

Conditions	Yield
With sodium hydroxide In water Product distribution;	A 92 % Chromat. B 85 % Chromat.

perfluoro-2-methylpentan-3-one (756-13-8) + dimethyl sulfate (77-78-1) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With potassium fluoride In diethylene glycol dimethyl ether at 45℃;

pyrrolidine (123-75-1) + perfluoro-2-methylpentan-3-one (756-13-8) → N-tetramethyleneperfluoropropanamide (686720-34-3) + 1,1,1,2,3,3,3-Heptafluoropropane (431-89-0) + N-butyl pentafluoropropionamide (309-24-0)

Conditions	Yield
With freon 11

perfluoro-2-methylpentan-3-one (756-13-8) + diethylamine (109-89-7) → C9H12F5NO (21016-40-0) + 1,1,1,2,3,3,3-Heptafluoropropane (431-89-0) + N-Diethyl-pentafluor-propionsaeureamid (10186-77-3) + ethylamine pentafluoropropionate

Conditions	Yield
With freon 11

perfluoro-2-methylpentan-3-one (756-13-8) + N-butylamine (109-73-9) → 1,1,1,2,3,3,3-Heptafluoropropane (431-89-0) + (butylidene)butylamine (4853-56-9) + N-butyl pentafluoropropionamide (309-24-0)

Conditions	Yield
With freon 11

perfluoro-2-methylpentan-3-one (756-13-8) → pentafluoropropionic acid (422-64-0)

Conditions	Yield
With water pH=8 - 14;

Upstream product

• 116-15-4 perfluoropropylene 
• 422-61-7 perfluoropropanoyl fluoride 
• 428-59-1 Hexafluoropropene oxide 
• 116-14-3 polytetrafluoroethylene 
• 677-84-9 perfluoroisobutyryl fluoride 
• 2070-70-4 perfluoro-4-methyl-2-pentene 
• 788-67-0 1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane 
• 57-13-6 urea 
• 3709-71-5 trans-perfluoro-(4-methyl-2-pentene) 
• 1584-03-8 perfluoro-2-methylpent-2-ene 
• 83714-48-1 2-chloroundecafluoro-2-methyl-3-pentanone 
• 103697-21-8 2,3-epoxyperfluoro-3-isopropyl-4-methylpentane 
• 788-50-1 trans-2,3-epoxyperfluoro-4-methylpentane 
• 75677-98-4 2,3-bi(fluorosulfato)perfluoro-4-methylpentane 

Downstream Products

• 422-64-0 pentafluoropropionic acid 
• 431-89-0 1,1,1,2,3,3,3-Heptafluoropropane 
• 4853-56-9 (butylidene)butylamine 
• 309-24-0 N-butyl pentafluoropropionamide 
• 21016-40-0 C₉H₁₂F₅NO 
• 10186-77-3 N-Diethyl-pentafluor-propionsaeureamid 
• 686720-34-3 N-tetramethyleneperfluoropropanamide 
• 132182-92-4 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane 
• 116-15-4 perfluoropropylene 
• 422-61-7 perfluoropropanoyl fluoride 

Relevant articles and documents

Method for synthesizing perfluoro(2-methyl-3-pentanone)

The invention discloses a method for synthesizing perfluoro(2-methyl-3-pentanone). The method comprises the following steps: in the presence of a polar aprotic solvent, carrying out an isomerization synthesis reaction in a micro-channel reactor by taking perfluoro-2,3-epoxy-2-methylpentane as a raw material and using an organic amine or metal fluoride as a catalyst to obtain a reaction product, and sequentially carrying out standing separation and rectification treatment on the reaction product to obtain perfluoro(2-methyl-3-pentanone). According to the invention, a reaction is performed by using a micro-channel reactor, so that the whole isomerization synthesis reaction cannot contact water or water vapor so as to avoid the generation of by-products and improve the conversion rate and theyield of the perfluoro(2-methyl-3-pentanone); and raw materials and a catalyst are subjected to high-speed uniform mixing and heat and mass transfer in the micro-channel reactor, so that the rate ofthe synthesis reaction is increased, the continuous and efficient synthesis of perfluoro(2-methyl-3-pentanone) is realized, and the method is good in repeatability, rapid in system response, easy forautomatic control and amplified production, almost free of amplification effect, high in safety, less in three wastes and easy for industrial production.

Preparation method of perfluoroketone

The invention discloses a preparation method of perfluoroketone. According to the preparation method, in an organic solvent, in the presence of a catalyst metal fluoride and a cosolvent, an addition reaction is performed on perfluoroolefin R1R2C=CR3R4 (R1, R2, R3 and R4 adopt a general formula of CnF2n+1 and n is a non-negative integer set) and acyl fluoride R5-COF (R5 adopts a general formula ofCmF2m+1 and m is a non-negative integer set) to obtain the perfluoroketone CFR3R4-CR1R2-COR5 (R5 is perfluoroalkyl) or CFR3R4-CR1R2-C(O)-CR1R2-CFR3R4 (R5 is an F atom). By the preparation method, theperfluoroolefins and the acyl fluoride are easy to obtain and low in price and the yield of perfluoroketone is high; a route is easy to industrialize.

Method for preparing pentafluoride ethyl perfluoro isopropyl ketone through gas phases

The invention discloses a method for preparing pentafluoride ethyl perfluoro isopropyl ketone through gas phases. The method is characterized in that under the existence of addition catalysts, hexafluoropropylene and hexafluoropropylene oxide or pentafluoropropionyl fluoride take gas phase addition reaction to obtain the pentafluoride ethyl perfluoro isopropyl ketone, or tetrafluoroethylene and heptafluorobutyl fluoride take gas phase addition reaction to obtain the pentafluoride ethyl perfluoro isopropyl ketone. The method has the advantages that the reaction route is short; in addition, rawmaterials such as the hexafluoropropylene, the tetrafluoroethylene, the hexafluoropropylene oxide and carbonyl fluoride can be easily obtained; the cost is low; the yield of the pentafluoride ethyl perfluoro isopropyl ketone is high; the continuous large-scale industrial production can be realized through the route.

Preparation method of perfluoro-2-methyl-3-pentanone

The invention discloses a preparation method of perfluoro-2-methyl-3-pentanon. Under the catalysis of a nitrogen-containing compound, perfluoro-2,3-epoxy-2-methylpentane is re-arranged to form perfluoro-2-methyl-3-pentanone in an aprotic polar solvent. The mass ratio of the perfluoro-2,3-epoxy-2-methylpentane to the nitrogen-containing compound is (20 to 65) to 1, and the mass ratio of the perfluoro-2,3-epoxy-2-methylpentane to the aprotic polar solvent is (1 to 6) to 1; and the reaction temperature is 30 to 150 DEG C, and the reaction time is 1 to 15 hours. The preparation method has the advantages of simple process, low cost, high efficiency and environmental friendliness.

Method for preparing perfluoro ethyl isopropylacetone

The invention provides a preparation method of perfluorethyl isopropyl ketone. The preparation method specifically comprises the step of: with a hexafluoropropylene dipolymer mixture and perfluo-4-methyl-2-amylene or perfluo-2-methyl-2-amylene as raw materials, carrying out reaction processes such as olefin epoxidation, structural rearrangement of epoxide to prepare the perfluorethyl isopropyl ketone. An aprotic polar solvent, a catalyst and a phase transfer catalyst are used in a preparation process, high selectivity and high transformation rate of all steps of reactions are realized, and after a reaction mixture is simply separated so that an intermediate and a perfluorethyl isopropyl ketone product with high quality can be obtained. Meanwhile, a one-pot technology of double bond isomerization and epoxidation reaction is established. The preparation method provided by the invention has the characteristics that raw materials are easily available, the cost is low, reaction conditions are mild, operation is safe and simple, reaction selectivity and transformation rate are high, little environment influence is low; therefore, the preparation method is suitable for industrial application.

Preparation method of C6-fluoroketone

The invention discloses a preparation method of C6-fluoroketone. C6-fluoroketone is called perfluoro-2-methyl-3-pentanone. The method includes the steps that in the presence of an organic guanidine catalyst and a solvent, perfluoro-2,3-epoxy-2-methylpentane reacts for 1-5 hours at the temperature of 0-80 DEG C; the organic guanidine catalyst is selected from one of or a mixture of two or more of metformin, bicyclic guanidine, chlorination bicyclic guanidine, tetramethyl guanidine and conjugated tetramethyl guanidine and other guanidyl compounds. The mole yield of the product obtained through the method is larger than 95%, reaction selectivity is high, reaction conditions are mild, and the preparation method is environmentally friendly.

PREPARATION METHOD FOR PERFLUORO-2-METHYL-3-PENTANONE AND INTERMEDIATE

Disclosed is a preparation method for perfluoro-2-methyl-3-pentanone. In the presence of fluoride salts and ether compounds, perfluoro-2, 3-epoxide-2-methyl pentane is converted into perfluoro-2-methyl-3-pentanone by a catalytic rearrangement reaction, which has characteristics such as mild action condition, fast reaction rate, high reaction selectivity and high yield. The prepared perfluoro-2-methyl-3-pentanone can be used as detergent, solvent and extinguishant. The perfluoro-2, 3-epoxide-2-methyl pentane is prepared by using perfluoro-2-methyl-2-amylene as raw material to react with sodium hypochlorite, and the perfluoro-2-methyl-2-amylene raw material is prepared through the catalytic isomerization reaction by using perfluoro-4-methyl-2-amylene as raw material.

Catalytic synthesis of certain perfluorinated ketones and study of their structure by 19F NMR spectroscopy

An efficient catalyst of a perfluorinated ketone synthesis of a high selectivity in the absence of solvent was proposed. Products of reaction of perfluorinated fluorides of various structures with tetrafluoroethylene and hexafluoropropylene in the presence of efficient catalysts without solvent were examined. The structure of the resulting products and their isomeric composition were identified by 19F NMR spectrscopy. Pleiades Publishing, Ltd., 2013.

Development of technology of perfluoroethyl isopropyl ketone production

Synthesis of perfluoroethyl isopropyl ketone by an interaction of hexafluoropropene with perfluoropropionic acid fluoride or hexafluoropropene oxide was examined. Interchangeability of perfluoropropionic acid fluoride and hexafluoropropene oxide was demonstrated. The features of perfluoroethyl isopropyl ketone synthesis were studied in polar aprotic solvents on catalysts: alkali metal fluoride. A method for obtaining perfluoroethyl isopropyl ketone by direct catalytic reaction in a tubular reactor without use of solvents was suggested and investigated. The mechanism of interaction was considered. The main impurities resulting in obtaining perfluoroethyl isopropyl ketone were determined. The methods of cleaning perfluoroethyl isopropyl ketone were worked out.

2,3-Epoxyperfl uoro-2-methylpentane in reactions with urea and thiourea

2,3-Epoxyperfl uoro-2-methylpentane reacts with thiourea in protic (methanol, 2-propanol) and aprotic (dioxane) solvents, and also with urea in acetonitrile affording unexpected products: 1-(2,2,3,3,3-pentafl uoropropionyl)- 2-(2,2,2-trifl uoro-1-trifl uoro-methylethyl)isothiourea, and 1-(2,2,3,3,3-pentafl uoropropionyl)-3-(2,2,2-trifl uoro-1- trifl uoro-methylethyl)urea respectively that result from the rearrangement of the intermediately formed ketone in the process of the intramolecular "haloform" cleavage. At the same time in dioxane the 2,3-epoxyperfl uoro- 2-methylpentane reacts with urea with the formation of a heterocyclic compound, 2-amino-4-pentafl uoroethyl- 5,5-bis(trifl uoromethyl)-4,5- dihydrooxazol-4-ol. From 1-(2,2,3,3,3-pentafl uoropropionyl)-2-(2,2,2-trifl uoro-1- trifl uoromethylethyl)isothiourea and Cu(OAc)2 a stable fl uorine-containing chelate complex was obtained. Pleiades Publishing, Ltd., 2011.