7504-90-7

Basic information

• Product Name: 2,5-dimethoxy-2,5-dimethyl-1,4-dioxane
• Synonyms: 1,4-Dioxane, 2,5-dimethoxy-2,5-dimethyl-; 2,5-Dimethoxy-2,5-dimethyl-1,4-dioxane
• CAS NO: 7504-90-7
• Molecular Formula: C₈H₁₆O₄
• Molecular Weight: 176.2102
• Mol File: 7504-90-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 201.6°C at 760 mmHg
• Flash Point: 75.8°C
• Density: 1.04g/cm³
• Vapor Pressure: 0.433mmHg at 25°C
• Refractive Index: 1.435
• CAS DataBase Reference: 2,5-dimethoxy-2,5-dimethyl-1,4-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethoxy-2,5-dimethyl-1,4-dioxane(7504-90-7)
• EPA Substance Registry System: 2,5-dimethoxy-2,5-dimethyl-1,4-dioxane(7504-90-7)

Safety Data

• Hazardous Substances Data: 7504-90-7(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Sweet, floral

Uses

Solvent, manufacturing of perfumes, fragrances, and flavorings; production of pharmaceuticals; solvent in extraction of natural products; coupling agent in production of epoxy resins

Precautions

Harmful if ingested, inhaled, or comes into contact with the skin

Upstream product

• 7664-41-7 ammonia 
• 116-09-6 hydroxy-2-propanone 
• 67-56-1 methanol 
• 107-19-7 propargyl alcohol 

Downstream Products

• 67-56-1 methanol 
• 116-09-6 hydroxy-2-propanone 
• 79-20-9 acetic acid methyl ester 
• 592-20-1 Acetol acetate 
• 7707-85-9 pyruvaldehyde bis-phenylhydrazone 

Relevant articles and documents

Isolable gold(I) complexes having one low-coordinating ligand as catalysts for the selective hydration of substituted alkynes at room temperature without acidic promoters

Hydration of a wide range of alkynes to the corresponding ketones has been afforded in high yields at room temperature by using gold(I)-phosphine complexes as catalyst, with no acidic cocatalysts required. Suitable substrates covering alkyl and aryl terminal alkynes, enynes, internal alkynes, and propargylic alcohols, including enantiopure forms, are cleanly transformed to the corresponding ketones in nearly quantitative yields. Acid-labile groups present in the substrates are preserved. The catalytic activity strongly depends on both the nature of the phosphine coordinated to the gold (I) center and the softness of the counteranion, the complex AuSPhOsNTf2 showing the better activity. A plausible mechanism for the hydration of alkynes through ketal intermediates is proposed on the basis of kinetic studies. The described catalytic system should provide an efficient alternative to mercury-based methodologies and be useful in synthetic programs.