74706-78-8

Basic information

• Product Name: 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl ester
• CAS NO: 74706-78-8
• Molecular Formula: C44H40Cl2N3O11P
• Molecular Weight: 888.695
• Mol File: 74706-78-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl ester(74706-78-8)
• EPA Substance Registry System: 3'-Thymidylic acid, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-, 2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl ester(74706-78-8)

Safety Data

• Hazardous Substances Data: 74706-78-8(Hazardous Substances Data)

Upstream product

• 103-45-7 acetic acid phenethyl ester 
• 53676-18-9 2,5-dichlorophenyl phosphorodichloridate 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 

Downstream Products

• 74706-88-0 C₅₄H₆₄N₅O₁₅PSi 
• 74706-87-9 C₄₈H₅₀N₅O₁₅P 
• 74706-95-9 C₅₆H₅₈N₆O₂₀P₂*C₆H₁₅N 
• 74706-93-7 C₆₂H₆₀Cl₂N₆O₂₀P₂ 
• 74712-84-8 Triaethylammonium(5'-O-monomethoxytritylthymidin-3')(p-nitrophenylaethyl)phosphat 
• 100-13-0 4-nitrostyrene 
• 74706-86-8 (Thymidin-3')(2,5-dichlorphenyl)(p-nitrophenylaethyl)phosphorsaeureester 

Relevant articles and documents

Nucleotides; XXIII. Synthesis of Protected 2'-Deoxyribonucleoside-3'-phosphotriesters containing the p-Nitrophenylethyl Phosphate Blocking Group

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New improvements in oligonucleotide synthesis by use of the p-nitrophenylethyl phosphate blocking group and its deprotection by DBU or DBN

Phosphate protection in the phosphotriester approach is improved by the new, versatile p-nitrophenylethyl group due to its stability in the condensation step and its clean removal by DBU and DBN respectively.