74654-05-0 Usage
Description
Methyl-PEG3-MS, also known as m-PEG4-Ms, is a PEG (polyethylene glycol) linker containing a mesyl group. The mesyl group serves as an excellent leaving group for nucleophilic substitution reactions, while the hydrophilic PEG spacer enhances solubility in aqueous media. This unique structure makes Methyl-PEG3-MS a versatile molecule with potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Methyl-PEG3-MS is used as a molecular linker for improving the solubility and bioavailability of drugs. The hydrophilic PEG spacer increases the drug's solubility in aqueous environments, while the mesyl group facilitates nucleophilic substitution reactions, allowing for the attachment of various drug molecules.
Used in Chemical Synthesis:
In the field of chemical synthesis, Methyl-PEG3-MS serves as a versatile building block for the creation of complex molecules. The mesyl group's reactivity as a leaving group enables the formation of new chemical bonds through nucleophilic substitution reactions, making it a valuable component in the synthesis of various compounds.
Used in Bioconjugation:
Methyl-PEG3-MS is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The PEG spacer provides a hydrophilic environment that can reduce aggregation and non-specific interactions, while the mesyl group allows for efficient coupling through nucleophilic substitution.
Used in Drug Delivery Systems:
In drug delivery systems, Methyl-PEG3-MS can be utilized as a component of targeted drug carriers. The PEG spacer can improve the solubility and circulation time of the drug in the body, while the mesyl group can be used to attach targeting ligands or other functional groups to enhance the specificity and efficacy of the drug delivery system.
Overall, Methyl-PEG3-MS is a multifunctional molecule with a wide range of applications in various industries, including pharmaceuticals, chemical synthesis, bioconjugation, and drug delivery systems. Its unique structure, combining a hydrophilic PEG spacer with a reactive mesyl group, makes it a valuable tool for improving solubility, bioavailability, and reactivity in a variety of contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 74654-05-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,6,5 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 74654-05:
(7*7)+(6*4)+(5*6)+(4*5)+(3*4)+(2*0)+(1*5)=140
140 % 10 = 0
So 74654-05-0 is a valid CAS Registry Number.
74654-05-0Relevant articles and documents
NEUROACTIVE STEROIDS AND COMPOSITIONS AND METHODS THEREOF
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Paragraph 00241, (2021/06/11)
The invention provides novel neuroactive steroids and pharmaceutical compositions thereof, as well as methods of their preparation and use, in therapy of various diseases and conditions, for example, various neurological or brain diseases.
MULTI-ELECTRON REDOX-ACTIVE ORGANIC MOLECULES FOR HIGH-ENERGY-DENSITY NONAQUEOUS REDOX FLOW BATTERIES
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Page/Page column 10-12, (2020/12/11)
The invention relates to 1,4-diaminoanthraquinones and an electrolyte, and their use in batteries.
DENDRITIC POLYETHYLENE GLYCOL DERIVATIVE, AND PREPARATION METHOD AND APPLICATION THEREOF
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Paragraph 0154, (2020/05/14)
The disclosure discloses a dendritic polyethylene glycol derivative and a preparation method and an application thereof. The dendritic polyethylene glycol derivative has a structure of formula (I), has multiple end functional groups, has a stronger water solubility in comparison with linear-chain polyethylene glycol, and can solve a problem of insufficient water solubility due to the increase of load when modifying an insoluble drug by the polyethylene glycol. The preparation method of the dendritic polyethylene glycol derivative provided by the disclosure has mild reaction conditions, is green and environmentally friendly, is low in cost, and is easy to implement industrialization.