74252-65-6

Basic information

• Product Name: 1,1,1-Trimethoxy-3-methylbutane
• Synonyms: 1,1,1-Trimethoxy-3-methylbutane
• CAS NO: 74252-65-6
• Molecular Formula: C₈H₁₈O₃
• Molecular Weight: 0
• Mol File: 74252-65-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 149.2°C at 760 mmHg
• Flash Point: 45.5°C
• Appearance: /
• Density: 0.9g/cm³
• Vapor Pressure: 5.17mmHg at 25°C
• Refractive Index: 1.406
• CAS DataBase Reference: 1,1,1-Trimethoxy-3-methylbutane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-Trimethoxy-3-methylbutane(74252-65-6)
• EPA Substance Registry System: 1,1,1-Trimethoxy-3-methylbutane(74252-65-6)

Safety Data

• Hazardous Substances Data: 74252-65-6(Hazardous Substances Data)

Usage

Physical state

Clear, colorless liquid

Odor

Slightly fruity

Usage

Solvent, fuel additive, pharmaceuticals, and pesticides manufacturing

Octane rating

High, useful in gasoline blends for efficient fuel combustion

Flammability

Flammable, requires careful handling

Volatility

Volatile organic compound (VOC), can contribute to air pollution if released

Safety

Must be handled and stored according to strict guidelines to prevent accidents and environmental harm

InChI:InChI=1/C8H18O3/c1-7(2)6-8(9-3,10-4)11-5/h7H,6H2,1-5H3

Upstream product

• 625-28-5 Isovaleronitrile 
• 67-56-1 methanol 

Downstream Products

• 67-56-1 methanol 
• 556-24-1 methyl 3-methylbutanoate 
• 94168-79-3 (S)-3-(1H-Indol-3-yl)-2-(2-isobutyl-4-oxo-4H-quinazolin-3-yl)-propionic acid benzyl ester 

Relevant articles and documents

Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3

A series of nine L-2,4-s;yrc-4-alkylglutamic acid analogues (1a-i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their corresponding 4-substituted ketoglutaric acids (2a-i), using the enzyme aspartate aminotransferase (AAT) from pig heart or E. coli. The synthesized compounds were evaluated as potential ligands for the glutamate transporters EAAT1, EAAT2, and EAAT3 (excitatory amino acid transporter, subtypes 1-3) in the FLIPR membrane potential (FMP) assay. We found a distinct change in the pharmacological profile when the 4-methyl group (compound 1a, an EAAT1 substrate and EAAT2,3 inhibitor) was extended to a 4-ethyl group, compound 1b, as this analogue is an inhibitor at all three subtypes, EAAT1-3. Furthermore, we conclude that both large and bulky hydrophobic substituents in the 4-position of L-2,4-syn Glu are allowed by all three glutamate transporter subtypes EAAT1-3 while maintaining inhibitory activity.