7404-50-4Relevant articles and documents
Study of the structure of (carbamimidoylsulfanyl)acetic ("pseudothiohydantoic") acid by XRD and PM6 methods
Fundamenskii,Ramsh,Brouskov,Smirnova,Yanichev,Fleisher,Belyakov
, p. 672 - 677 (2013)
It was shown by the method of powder X-ray diffraction analysis that in the crystalline state the product of the reaction of thiourea with chloroacetic acid in water, (carbamimidoylsulfanyl)acetic acid, existed in the zwitter-ion tautomeric form. The structure consists of virtually planar infi nite layers normal to the c axis of the unit cell which are bound by van der Waals interactions. The layers are formed by infi nite rows elongated along the b axis of the unit cell consisting of materially planar zwitter-ionic molecules linked by strong bifurcated hydrogen bonds. The results of quantum-chemical calculations by PM6 method are in agreement with the XRD results: whereas an isolated molecule exists in nonzwitter-ionic tautomeric form, in the crystal only the zwitterionic tautomer is present.
Clean production method of mercaptan compound
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Paragraph 0021; 0024, (2017/01/02)
The invention provides a clean production method of a mercaptan compound. There are two technological steps: Step 1, thiourea and halogenated hydrocarbon or active conjugated alkene react at 20-150 DEG C for 1-18 h, and after neutralization, S-alkylisothiourea is obtained; and Step 2, S-alkylisothiourea and aliphatic primary amine or secondary amine react at 20-180 DEG C for 1-24 h to obtain the mercaptan compound, and simultaneously, a substituted guanidino compound is coproduced. The mercaptan production technology has mild condition and high yield, hardly has discharge of ''three wastes (waste gas, waste water and industrial residue) '', and is a clean production method.
Synthesis of (aminoiminomethyl)thioacetic acid and some of its esters
Grozav, Ma?a,Neam?iu, Ileana,Mercea, Maria,Laichici, Maria,Fǎgǎdar-Cosma, Eugenia
, p. 1235 - 1241 (2007/10/03)
The aim of this paper was to find the simplest method for the synthesis of (aminoiminomethyl)thioacetic acid and some of its esters ( methyl- and ethyl-) in order to test them biologically as potential plant growth regulators.
Synthesis and alkylation of hexahydro-1,3,5-triazine-2-thione derivatives
Lazarev,Ramsh,Ivanenko
, p. 442 - 449 (2007/10/03)
A series of new hexahydro-1,3,5-triazine-2-thione derivatives were prepared by aminomethylation of thiourea with formaldehyde and primary amines; with aniline as amine component, an abnormal aminomethylation product is formed, 5-phenyl-1-phenylaminomethylhexahydro-1,3,5-triazine-2-thione. Alkylation of 5-tert-butylhexahydro-1,3,5-triazine-2-thione with alkyl halides and with methyl and ethyl bromoacetate yields hydrohalides of 2-alkylthio- and 2-alkoxycarbonylmethylthio-5-tert-butyl-3,4,5,6-tetrahydro-1,3,5-triazines, respectively.
Reactions of Thiourea with Chloro- and Bromoacetic Acids
Kavalek, Jaromir,Said-El-Bahaie,Sterba, Vojeslav
, p. 263 - 268 (2007/10/02)
The reaction of chloroacetic acid with thiourea represents an SN2 substitution of chlorine by sulphur atom and is about two orders of magnitude slower than that of bromoacetic acid.Chloroacetate ion reacts slower than chloroacetic acid by only about 30percent.The acid catalyzed splitting off of hydroxyl group from the formed tetrahedral intermediate is rate-limiting in the cyclization of the S-carboxylatomethyleneisothiouronium salt, formation of the intermediate being rate-limiting below pH 2.