73870-24-3 Usage
Description
4-(Bromomethyl)pyridine hydrobromide is an organic compound that features a pyridine ring with a bromomethyl group attached to the 4-position. 4-(Bromomethyl)pyridine hydrobromide is a valuable intermediate in the synthesis of various organic and pharmaceutical compounds due to its unique structure and reactivity.
Uses
Used in Pharmaceutical Industry:
4-(Bromomethyl)pyridine hydrobromide is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its ability to form new chemical entities makes it a versatile building block in the development of new drugs.
Used in Organic Synthesis:
4-(Bromomethyl)pyridine hydrobromide is used as a key intermediate in the synthesis of complex organic molecules. Its reactivity allows for the formation of new carbon-carbon and carbon-heteroatom bonds, facilitating the creation of diverse molecular structures.
Specific Applications:
4-(Bromomethyl)pyridine hydrobromide is used in the preparation of the following compounds:
1. 3-(4-pyridylmethyl)-2′,3′-di-O-oleyl-5′-O-(4,4′-dimethoxytriphenylmethyl)uridine: 4-(Bromomethyl)pyridine hydrobromide is synthesized using 4-(Bromomethyl)pyridine hydrobromide as a starting material, and it may have potential applications in the field of nucleoside chemistry.
2. 3-(4-pyridylmethyl)-3′-O-oleyl-5′-O-(4,4-dimethoxytriphenylmethyl)-thymidine: Another nucleoside derivative that can be synthesized using 4-(Bromomethyl)pyridine hydrobromide, potentially useful in the study of nucleic acid chemistry.
3. 1,4-bis(N-hexyl-4-pyridinium)butadiene diperchlorate: 4-(Bromomethyl)pyridine hydrobromide can be prepared using 4-(Bromomethyl)pyridine hydrobromide and may have applications in the field of conductive polymers or materials science.
Additionally, 4-(Bromomethyl)pyridine hydrobromide is used in the preparation of benzoxazine derivatives, which have potential applications in various fields:
1. 2-morpholin-4-yl-7-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one: A benzoxazine derivative that can be synthesized using 4-(Bromomethyl)pyridine hydrobromide, potentially useful in the development of new pharmaceutical agents or materials.
2. 8-methyl-2-morpholin-4-yl-7-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one: Another benzoxazine derivative with potential applications in various industries.
3. 2-morpholin-4-yl-8-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one: 4-(Bromomethyl)pyridine hydrobromide can also be prepared using 4-(Bromomethyl)pyridine hydrobromide and may have potential uses in the pharmaceutical or materials science sectors.
Check Digit Verification of cas no
The CAS Registry Mumber 73870-24-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,3,8,7 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 73870-24:
(7*7)+(6*3)+(5*8)+(4*7)+(3*0)+(2*2)+(1*4)=143
143 % 10 = 3
So 73870-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H6BrN.BrH/c7-5-6-1-3-8-4-2-6;/h1-4H,5H2;1H
73870-24-3Relevant articles and documents
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation
Relitti, Nicola,Saraswati, A. Prasanth,Chemi, Giulia,Brindisi, Margherita,Brogi, Simone,Herp, Daniel,Schmidtkunz, Karin,Saccoccia, Fulvio,Ruberti, Giovina,Ulivieri, Cristina,Vanni, Francesca,Sarno, Federica,Altucci, Lucia,Lamponi, Stefania,Jung, Manfred,Gemma, Sandra,Butini, Stefania,Campiani, Giuseppe
, (2020/11/24)
In this work we describe the synthesis of potent and selective quinolone-based histone deacetylase 6 (HDAC6) inhibitors. The quinolone moiety has been exploited as an innovative bioactive cap-group for HDAC6 inhibition; its synthesis was achieved by applying a multicomponent reaction. The optimization of potency and selectivity of these products was performed by employing computational studies which led to the discovery of the diethylaminomethyl derivatives 7g and 7k as the most promising hit molecules. These compounds were investigated in cellular studies to evaluate their anticancer effect against colon (HCT-116) and histiocytic lymphoma (U9347) cancer cells, showing good to excellent potency, leading to tumor cell death by apoptosis induction. The small molecules 7a, 7g and 7k were able to strongly inhibit the cytoplasmic and slightly the nuclear HDAC enzymes, increasing the acetylation of tubulin and of the lysine 9 and 14 of histone 3, respectively. Compound 7g was also able to increase Hsp90 acetylation levels in HCT-116 cells, thus further supporting its HDAC6 inhibitory profile. Cytotoxicity and mutagenicity assays of these molecules showed a safe profile; moreover, the HPLC analysis of compound 7k revealed good solubility and stability profile.
Semiconductor quantum dots photosensitizing release of anticancer drug
Liu, Zhenzhen,Lin, Qiuning,Huang, Qi,Liu, Hui,Bao, Chunyan,Zhang, Wenjin,Zhong, Xinhua,Zhu, Linyong
supporting information; experimental part, p. 1482 - 1484 (2011/03/20)
A new photo-controlled anticancer drug release system is reported based on the photo-induced electron transfer (PET) between semiconductor quantum dots (QDs) and N-methyl-4-picolinium (NAP) ester 1 under the excitation of visible light.
PIPERIDINONES USEFUL IN THE TREATMENT OF INFLAMMATION
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Page/Page column 113, (2008/12/07)
There is provided compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, m and n have meanings given in the description, and pharmaceutically acceptable derivatives thereof, which compounds are useful in the treatment of diseases and conditions associated with inflammation.
