7294-84-0Relevant articles and documents
Structural Insights into the TES/TFA Reduction of Differently Substituted Benzofurans: Dihydrobenzofurans or Bibenzyls?
D'Orsi, Rosarita,Caivano, Ilaria,Funicello, Maria,Lupattelli, Paolo,Chiummiento, Lucia
supporting information, p. 63 - 64 (2020/11/04)
Various polysubstituted benzofurans were reduced by using triethylsilane in trifluoracetic acid. 2,3-Dihydrobenzofurans or bibenzyl compounds were obtained in high yields, depending on the nature of the substituents at C2 and on the benzene ring of the co
Preparation method of ortho-alkylphenol
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Paragraph 0008; 0010, (2019/01/14)
The invention relates to a preparation method of ortho-alkylphenol. A 2-(2-alkylphenoxy) pyridine derivative is used as a raw material to prepare the ortho-alkylphenol. The reaction process includes:directly adding the 2-(2-alkylphenoxy) pyridine derivati
Naturally occurring Batatasins and their derivatives as α-glucosidase inhibitors
Hu, Wei-Ping,Cao, Guo-Dong,Zhu, Jin-Hua,Li, Jia-Zhong,Liu, Xiu-Hua
, p. 82153 - 82158 (2015/10/12)
Batatasins are endogenous plant hormones found in yams and other related plant species. These plants are widely consumed as botanical dietary supplements in many parts of the world. This study investigated the inhibitory effects and mechanisms of Batatasin I, III, IV, V against α-glucosidase regarding their antidiabetic activities. The results revealed that Batatasin I, III, IV inhibited α-glucosidase in a reversible and noncompetitive manner, with IC50 values of 2.55, 1.89 and 2.52 mM respectively, while Batatasin V completely abolished its inhibitory activity even at the highest concentrations tested. Furthermore, a class of Batatasin-derived compounds with different substitution patterns was synthesized and subjected to the assay to clarify the structure-activity relationships, which suggested that the hydroxyl at the C-2′ position may play a significant role in improving the inhibitory activities. Their probable binding modes and the specificity of the binding sites were studied using molecule docking simulation. It was concluded that Batatasins, especially Batatasin III and IV, are promising α-glucosidase inhibitors, which therefore could be used as functional food to alleviate postprandial hyperglycemia and as potential candidates for the development of antidiabetic agents.