7217-59-6 Usage
Description
2-Methoxybenzenethiol, also known as 2-methoxythiophenol, is a sulfur-containing compound characterized by its clear yellow to colorless-yellow liquid appearance and a pungent, onion-like aroma. It possesses a meaty sausage taste at a threshold value of 1 ppm in water and is known for its very high strength odor, making it suitable for use as a flavoring agent in the food industry.
Uses
Used in Pharmaceutical Applications:
2-Methoxybenzenethiol is utilized in the synthesis of various multifunctional agents, such as berberine-thiophenyl hybrids. These agents exhibit inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and AB aggregation, as well as antioxidant activity. This makes them valuable in the development of drugs targeting neurodegenerative diseases and other conditions related to oxidative stress.
Used in Chemical Synthesis:
2-Methoxybenzenethiol is also used in the synthesis of various chemical compounds, including (4S)-N-[(2S)-2-methy-3-(2-methoxyphenylthio)propanoyl]-4-phenyloxazolidin-2-one, 2-(4-fluorophenyl)-6-(2-methoxyphenylsulfanyl)imidazo[1,2-a]pyridine, and 2-(2-methoxyphenylsulfanyl)benzoic acid. These synthesized compounds have potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals.
Used in Flavor and Fragrance Industry:
As a flavoring agent, 2-methoxybenzenethiol is used to impart a meaty sausage taste to various food products. Its strong aroma makes it suitable for use in the fragrance industry as well, where it can be employed to create complex and nuanced scents.
Check Digit Verification of cas no
The CAS Registry Mumber 7217-59-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,1 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7217-59:
(6*7)+(5*2)+(4*1)+(3*7)+(2*5)+(1*9)=96
96 % 10 = 6
So 7217-59-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H8OS/c1-8-6-4-2-3-5-7(6)9/h2-5,9H,1H3/p-1
7217-59-6Relevant articles and documents
SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF
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Paragraph 0032; 0033; 0063; 0067; 0068; 0070, (2017/09/02)
The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017
Copper-Catalyzed Direct Synthesis of Aryl Thiols from Aryl Iodides Using Sodium Sulfide Aided by Catalytic 1,2-Ethanedithiol
Xue, Hongyu,Jing, Bing,Liu, Shasha,Chae, Junghyun,Liu, Yajun
, p. 2272 - 2276 (2017/10/06)
A copper-catalyzed direct and effective synthesis of aryl thiols from aryl iodides using readily available Na 2 S·9H 2 O and 1,2-ethanedithiol was described. A variety of aryl thiols were readily obtained in yields of 76-99%. In this protocol, Na 2 S·9H 2 O was used as ultimate sulfur source, and 1,2-ethanedithiol functioned as an indispensable catalytic reagent.
Palladium catalyzed synthesis of aryl thiols: Sodium thiosulfate as a cheap and nontoxic mercapto surrogate
Yi, Jun,Fu, Yao,Xiao, Bin,Cui, Wei-Chen,Guo, Qing-Xiang
experimental part, p. 205 - 208 (2011/02/26)
A Pd-catalyzed coupling reaction of ArBr/ArCl/ArOTf with sodium thiosulfate takes place in presence of Cs2CO3 at 80 °C. The reaction mixture is directly treated with Zn/HCl to afford aryl thiols in good to excellent yields.