72093-04-0

Basic information

• Product Name: 3-CHLORO-4-METHYLPYRIDINE
• Synonyms: 3-CHLORO-4-PICOLINE;3-CHLORO-4-METHYLPYRIDINE;3-Chloro-4-methylpyridine 97%
• CAS NO: 72093-04-0
• Molecular Formula: C₆H₆ClN
• Molecular Weight: 127.57
• Product Categories: pharmacetical;Pyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series
• Mol File: 72093-04-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 175.6 °C at 760 mmHg
• Flash Point: 66 °C
• Appearance: Colorless to brown/Liquid
• Density: 1.159 g/mL at 25 °C
• Vapor Pressure: 1.53mmHg at 25°C
• Refractive Index: n20/D 1.5310
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3-CHLORO-4-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-METHYLPYRIDINE(72093-04-0)
• EPA Substance Registry System: 3-CHLORO-4-METHYLPYRIDINE(72093-04-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 72093-04-0(Hazardous Substances Data)

Usage

Description

3-Chloro-4-methylpyridine is an organic compound that serves as a valuable intermediate in the synthesis of various pharmaceuticals and biologically active molecules. Its unique structure, featuring a chloro and methyl group on a pyridine ring, allows for versatile chemical reactions and modifications, making it a key component in the development of new drugs and therapeutic agents.

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-methylpyridine is used as a building block for the synthesis of more complex pharmaceutical compounds. Its presence in the molecular structure of these compounds can contribute to their biological activity and therapeutic effects, making it an essential component in the development of new drugs.
Used in Biologically Active Compounds Synthesis:
3-Chloro-4-methylpyridine is also used as a key intermediate in the synthesis of biologically active compounds. Its unique structure allows for the creation of molecules with specific interactions and properties, which can be harnessed for various applications in the field of biology and medicine.

InChI:InChI=1/C6H6ClN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3

Upstream product

• 108-89-4 picoline 
• 626-60-8 3-Chloropyridine 
• 74-88-4 methyl iodide 
• 38113-08-5 3,4-dihydro-2-methoxy-4-methyl-2H-pyran 

Downstream Products

• 1259404-17-5 tasocitinib 
• 1325182-06-6 N-methyl-7-[(4-methylphenyl)sulfonyl]-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1354621-59-2 cis-N-benzyl-3-methoxycarbonylamino-4-methylpiperidine 
• 77862-24-9 4-Methyl-3-(methylamino)pyridine 
• 19352-29-5 methyl-4 phenyl-3 pyridine 
• 1501945-30-7 1-(4-((4-methylpyridin-3-yl)amino)phenyl)ethanone 
• 1438894-21-3 4-methyl-3-(2-methylphenyl)pyridine 
• 1402010-73-4 3-(1-(benzyloxy)-3-phenylpropyl)-4-methylpyridine 
• 1246547-22-7 N,N-dimethyl-2-((4-methylpyridin-3-yl)amino)benzamide 

Relevant articles and documents

ETUDE DES ortho-METALLATIONS REGIOSELECTIVES DE LA CHLORO-3 PYRIDINE PAR DES ORGANOLITHIENS ET DES AMIDURES DE LITHIUM; EFFET D'ORIENTATION PAR LE SOLVANT, APPLICATIONS A LA SYNTHESE

Lithium dialkylamides metalate 3-chloropyridine with excellent regioselectivity at position 4.This reaction occurs in THF solution at -60 deg C and it leads to various 3,4-disubstituted pyridines in good yields.This regioselectivity is completely changed in ether solution by using the butyllithium-TMEDA complex.In that case position 2 is metallated and 2,3-disubstituted pyridines are obtained.