7205-90-5

Basic information

• Product Name: CHLOROMETHYL 4-CHLOROPHENYL SULFIDE
• Synonyms: CHLOROMETHYL 4-CHLOROPHENYL SULFIDE;(4-Chlorophenyl)thiomethyl chloride;(p-Chlorophenylthio)methyl chloride;1-chloro-4-(chloromethylthio)-benzen;1-Chloro-4-(chloromethylthio)benzene;1-Chloro-4-[(chloromethyl)sulfanyl]benzene;1-chloro-4-[(chloromethyl)thio]-benzen;Chloromethyl p-chlorophenyl sulfide
• CAS NO: 7205-90-5
• Molecular Formula: C₇H₆Cl₂S
• Molecular Weight: 193.09
• EINECS: 230-578-1
• Product Categories: Organic Building Blocks;Sulfides/Disulfides;Sulfur Compounds
• Mol File: 7205-90-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 21.5°C
• Boiling Point: 128-129 °C12 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.348 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0183mmHg at 25°C
• Refractive Index: n20/D 1.6065(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CHLOROMETHYL 4-CHLOROPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROMETHYL 4-CHLOROPHENYL SULFIDE(7205-90-5)
• EPA Substance Registry System: CHLOROMETHYL 4-CHLOROPHENYL SULFIDE(7205-90-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• RTECS: CZ0200000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 7205-90-5(Hazardous Substances Data)

Usage

Description

Chloromethyl 4-chlorophenyl sulfide, also known as (phenylthio)methyl chloride, is an organic compound with the chemical formula C7H6Cl2S. It is a derivative of chloromethyl phenyl sulfide and features a chlorine atom attached to a phenyl ring with a sulfur atom connected to a chloromethyl group. CHLOROMETHYL 4-CHLOROPHENYL SULFIDE is known for its reactivity and is commonly used as a starting material in various chemical reactions and syntheses.

Uses

Used in Solvolysis Studies:
Chloromethyl 4-chlorophenyl sulfide is used as a subject of study in the solvolysis of chloromethyl phenyl sulfide and its p-chloro-derivative. This process involves the reaction of the compound with a wide range of hydroxylic solvents, providing valuable insights into the reactivity and behavior of the compound under different conditions.
Used in Synthesis of (4-Chlorophenylthio) Methyl Acetate:
Chloromethyl 4-chlorophenyl sulfide serves as a starting reagent in the synthesis of (4-chlorophenylthio) methyl acetate. This derivative has potential applications in various chemical and pharmaceutical industries, making the synthesis process an important application of the parent compound.
Used as Alkylating Reagent in Microwave-Assisted Synthesis:
Chloromethyl 4-chlorophenyl sulfide is utilized as an alkylating reagent in the microwave-assisted synthesis of 2-amino-imidazo[1,2-a]pyridine derivatives. These derivatives have potential applications in the development of new drugs and pharmaceutical compounds, highlighting the importance of the alkylating reagent in this process.

InChI:InChI=1/C7H6Cl2S/c8-5-10-7-3-1-6(9)2-4-7/h1-4H,5H2

Upstream product

• 106-54-7 p-Chlorothiophenol 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 74-97-5 chlorobromomethane 
• 112474-70-1 <(4-chlorophenylthio)methyl>trimethylsilane 
• 50-00-0 formaldehyd 
• 744221-72-5 (4-chloro-phenylsulfanyl)-methanesulfonic acid 
• 13150-73-7 3-chlorophenyl methyl sulfoxide 
• 123-09-1 4-chlorophenyl methyl sulfide 

Downstream Products

• 7173-84-4 S-(4-chlorophenylthio)methyl diethyl phosphorothiolate 
• 21309-07-9 cis-1-(4-chlorobenzenesulphonyl)-2-phenylcyclopropane 
• 953-17-3 Methyl Trithion 
• 332-18-3 (4-chloro-phenylsulfanyl)-(4-fluoro-phenylsulfanyl)-methane 
• 143552-07-2 [(1R,2R,3S)-2-{3-[(1R,2R,3S)-2-Benzoyl-3-(4-chloro-benzenesulfonyl)-cyclopropyl]-phenyl}-3-(4-chloro-benzenesulfonyl)-cyclopropyl]-phenyl-methanone 
• 143517-32-2 [(1R,2R,3S)-2-{4-[(1R,2R,3S)-2-Benzoyl-3-(4-chloro-benzenesulfonyl)-cyclopropyl]-phenyl}-3-(4-chloro-benzenesulfonyl)-cyclopropyl]-phenyl-methanone 
• 143517-57-1 {4-[(1S,2R,3S)-2-(4-Chloro-benzenesulfonyl)-3-(4-methoxy-phenyl)-cyclopropanecarbonyl]-phenyl}-[(1S,2R,3S)-2-(4-chloro-benzenesulfonyl)-3-(4-methoxy-phenyl)-cyclopropyl]-methanone 
• 143552-11-8 {3-[(1S,2R,3S)-2-(4-Chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropanecarbonyl]-phenyl}-[(1S,2R,3S)-2-(4-chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropyl]-methanone 
• 143517-64-0 {6-[(1S,2R,3S)-2-(4-Chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropanecarbonyl]-pyridin-2-yl}-[(1S,2R,3S)-2-(4-chloro-benzenesulfonyl)-3-(2,4-dimethoxy-phenyl)-cyclopropyl]-methanone 
• 101973-45-9 [Chloro-(4-chloro-phenylsulfanyl)-methyl]-phosphonic acid diethyl ester 
• 101973-42-6 [(4-Chloro-phenylsulfanyl)-methoxy-methyl]-phosphonic acid diethyl ester 
• 101973-43-7 [(4-Chloro-phenylsulfanyl)-ethoxy-methyl]-phosphonic acid diethyl ester 
• 83767-82-2 N-chloromethylformanilide 
• 67174-61-2 4-chlorophenylthiomethyl cyclopropane thiolcarboxylate 

Relevant articles and documents

Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments

2-(Arylsulfonyl)oxetanes have been prepared as new structural motifs of interest for medicinal chemistry. These are designed to fit within fragment space and be suitable for screening in fragment based drug discovery, as well as being suitable for further elaboration or incorporation into drug-like compounds. The oxetane ring is constructed through an efficient C-C bond forming cyclisation which allows the incorporation of a wide range of aryl-sulfonyl groups. Furthermore, biaryl-containing compounds can be accessed through Suzuki-Miyaura coupling from halogenated derivatives. With a number of oxetane containing fragment compounds available, their pH stability was assessed, indicating good half-life values for mono-substituted aryl sulfonyl oxetanes across the pH range (1 to 10). Solubility and metabolic stability data is also reported. Finally, the conformation of the fragments is assessed computationally, providing an indication of possible binding orientations.

A simple and efficient synthesis of trihalomethyl and dihalonitromethyl aryl sulfones

A method for the preparation of aryl trihalomethyl sulfones - active biocidal agents - with identical or different halogens is presented. The synthesis is based on the reaction of aryl methyl, aryl halomethyl, or aryl nitromethyl sulfones with sodium hypohalite. The method is simple in implementation, does not necessarily require the use of organic solvents, and selectively affords the products in good to excellent yields. Notably, it allows the preparation of the hitherto unknown phenyl trihalomethyl sulfone with three different halogens: fluorine, chlorine, and bromine.

Synthese et activite biologique de prodrogues de l'acide oxolinique

Synthesis and biological activities of oxolinic acid pro-drugs.Antiseptic phenols, anti-inflammatory acids and polyethyleneglycol moieties have been attached by labile bonds to oxolinic acid giving pro-drugs with anti-bacterial activities.Some of them are more soluble in water, exhibit a more sustained action in the time and give higher plasma and tissue concentrations compared with the free drug.