713143-67-0

Basic information

• Product Name: 5-(3-Fluorophenyl)-2-methyl-pyridin
• Synonyms: 5-(3-Fluorophenyl)-2-methyl-pyridin;5-(3-FLUOROPHENYL)-2-METHYLPYRIDINE;5-(3-Fluorophenyl)
• CAS NO: 713143-67-0
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.2129032
• Mol File: 713143-67-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 284.5°C at 760 mmHg
• Flash Point: 125.9°C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 0.00508mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.05±0.11(Predicted)
• CAS DataBase Reference: 5-(3-Fluorophenyl)-2-methyl-pyridin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-Fluorophenyl)-2-methyl-pyridin(713143-67-0)
• EPA Substance Registry System: 5-(3-Fluorophenyl)-2-methyl-pyridin(713143-67-0)

Safety Data

• Hazardous Substances Data: 713143-67-0(Hazardous Substances Data)

Usage

Uses

Due to the limited research on 5-(3-Fluorophenyl)-2-methyl-pyridin, its applications are not well-defined. However, based on its chemical structure and properties, it can be speculated that it may have potential uses in the following areas:
Used in Pharmaceutical Industry:
5-(3-Fluorophenyl)-2-methyl-pyridin could be used as an intermediate compound in the synthesis of pharmaceutical drugs. Its unique structure with a fluorophenyl and methyl group might be beneficial in the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
5-(3-Fluorophenyl)-2-methyl-pyridin may be used as a research compound in academic and industrial laboratories. Its electronegativity and reactivity could be studied to understand its behavior in various chemical reactions, potentially leading to the discovery of new reaction pathways or the development of novel synthetic methods.
Used in Material Science:
5-(3-Fluorophenyl)-2-methyl-pyridin could be explored for its potential applications in material science, such as in the development of new polymers or materials with specific properties. The presence of a fluorine atom might impart unique characteristics to the materials, making them suitable for various applications.

InChI:InChI=1/C12H10FN/c1-9-5-6-11(8-14-9)10-3-2-4-12(13)7-10/h2-8H,1H3

Upstream product

• 768-35-4 3-fluorophenylboronic acid 
• 111770-91-3 (6-methylpyridin-3-yl)trifluoromethanesulfonate 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 3430-13-5 5-bromo-2-methylpyridine 

Downstream Products

• 380894-77-9 [5-(3-fluorophenyl)-pyridin-2-ylmethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Discovery of Potent Orally Active Protease-Activated Receptor 1 (PAR1) Antagonists Based on Andrographolide

Protease-activated receptor-1 (PAR1), a G-protein-coupled receptor, plays a critical role in thrombin-mediated platelet aggregation. It is regarded as a promising antithrombosis target that is unlikely to result in bleeding. Here, we describe the synthesi

Discovery of octahydroindenes as PAR1 antagonists

Octahydroindene was identified as a novel scaffold for protease activated receptor 1 (PAR1) antagonists. Herein, the 2-position (C2) was explored for structure-activity relationship (SAR) studies. Compounds 14, 19, and 23b showed IC50 values of 1.3, 8.6, and 2.7 nM in a PAR1 radioligand binding assay, respectively, and their inhibitory activities on platelet activation were comparable to that of vorapaxar in a platelet rich plasma (PRP) aggregation assay. This series of compounds showed high potency and no significant cytotoxicity; however, the compounds were metabolically unstable in both human and rat liver microsomes. Current research efforts are focused on optimizing the compounds to improve metabolic stability and physicochemical properties as well as potency.

[6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES

The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.

Method for producing biaryl compounds

[PROBLEM TO BE SOLVED]: To provide method for producing biaryl compound in high purity and in high selectivity.[SOLUTION]: This method for producing the biaryl compound is characterized by coupling a halogenated aryl with a organomethallic aryl in the presence of a transition metal multidentate phosphite complex catalyst to obtain the biaryl compound.