7127-19-7Relevant articles and documents
Synthesis of (fluoroalkyl)amines by deoxyfluorination of amino alcohols
Nomoto, Takashi,Fukuhara, Tsuyoshi,Hara, Shoji
, p. 1744 - 1746 (2006)
Deoxyfluorination of amino alcohols was achieved using N,N-diethyl-α, α-difluorobenzylamine (DFBA) to furnish N-benzoyl(fluoroalkyl)amines selectively. Georg Thieme Verlag Stuttgart.
Facile one-pot synthesis of 2-oxazoline
Jiang, Weinan,Liu, Runhui,Song, Gonghua,Zhou, Min,Zhou, Yang,Zhu, Jipeng
supporting information, (2022/01/28)
We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.
Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones
Liu, Jidan,Yang, Zhenke,Jiang, Jinyuan,Zeng, Qiaohai,Zheng, Liyao,Liu, Zhao-Qing
supporting information, p. 5927 - 5931 (2021/07/31)
The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.
Ruthenium-catalysedmeta-selective CAr-H bond alkylationviaa deaminative strategy
Zhu, Ze-Fan,Chen, Guang-Le,Liu, Feng
supporting information, p. 3411 - 3414 (2021/04/07)
The use of aliphatic amines as alkylating reagents in organic synthesisviaC-N bond activation remains underdeveloped. We herein describe a novel ruthenium-catalysed and directing-group assisted protocol for the synthesis ofmeta-alkylated arenesviadual C-H and C-N activation. Bench-stable and easily handled redox-active Katritzky pyridinium salts derived from abundant amines and amino acid species were used as alkyl radical precursors. This catalytic reaction could accommodate a broad range of functional groups and provide access to variousmeta-alkylated products.
