71267-12-4 Usage
Description
5-Pyrimidinol, 2,4,6-trimethyl(6CI,9CI) is a pyrimidine derivative with the molecular formula C7H10N2O, featuring three methyl groups attached to the 2, 4, and 6 positions of the pyrimidine ring. This chemical compound is utilized in various organic synthesis reactions and serves as an intermediate in the pharmaceutical industry for the production of specific drugs. It also exhibits a range of biological activities and is being investigated for its potential therapeutic applications, as well as being used as a building block for the synthesis of more complex organic molecules.
Uses
Used in Pharmaceutical Industry:
5-Pyrimidinol, 2,4,6-trimethyl(6CI,9CI) is used as a chemical intermediate for the synthesis of certain drugs, contributing to the development of new medications and therapeutic agents.
Used in Organic Synthesis:
5-Pyrimidinol, 2,4,6-trimethyl(6CI,9CI) is employed as a reactant in various organic synthesis reactions, enabling the creation of a wide range of chemical products and materials.
Used in Research and Development:
5-Pyrimidinol, 2,4,6-trimethyl(6CI,9CI) is utilized in research settings to study its biological activities and explore its potential therapeutic applications, aiding in the advancement of medical and pharmaceutical knowledge.
Used in the Synthesis of Complex Organic Molecules:
As a building block, 5-Pyrimidinol, 2,4,6-trimethyl(6CI,9CI) is used in the assembly of more intricate organic molecules, which can have various applications in different industries, including pharmaceuticals, materials science, and chemical manufacturing.
Check Digit Verification of cas no
The CAS Registry Mumber 71267-12-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,2,6 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 71267-12:
(7*7)+(6*1)+(5*2)+(4*6)+(3*7)+(2*1)+(1*2)=114
114 % 10 = 4
So 71267-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2O/c1-4-7(10)5(2)9-6(3)8-4/h10H,1-3H3
71267-12-4Relevant articles and documents
An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors
Renard, Brice-Lo?c,Boucherle, Benjamin,Maurin, Bruno,Molina, Marie-Carmen,Norez, Caroline,Becq, Frédéric,Décout, Jean-Luc
experimental part, p. 1935 - 1941 (2011/05/02)
In the study of previously reported modulators of CFTR chloride channels that are cyclic methylglyoxal (MG) diadducts (CMGD) to aromatic α-aminoazaheterocycles, we optimized a new expeditious one pot route for preparing in water novel aromatic polycyclic azaheterocycles and described 5-pyrimidinols antioxidants through the formation of 2-oxoaldehyde diadducts to aromatic α-aminoazaheterocycles, amidines, guanidines and thiourea. In regard to the importance as biomarkers of diabetic complications of the 5-pyrimidinols "argpyrimidines" formed in proteins from MG and arginine residues, we demonstrated that argpyrimidines are slowly formed under physiological conditions from CMGD to arginine derivatives according to the synthesis route described. Among the 5-pyrimidinol derivatives prepared, two polycyclic derivatives appeared to inhibit strongly the activity of CFTR channels in wt-CHO cells.
Novel chain-breaking antioxidants
-
, (2008/06/13)
Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.