71115-83-8

Basic information

• Product Name: FA-PHE-OH
• Synonyms: FA-PHE-OH;FA-PHENYLALANINE;3-(2-FURYL)ACRYLOYL-L-PHENYLALANINE;N-[3-(2-FURYL)ACRYLOYL]-L-PHENYLALANINE;N-ALPHA-(3-(2-FURYL)ACRYLOYL)-L-PHENYLALANINE
• CAS NO: 71115-83-8
• Molecular Formula: C₁₆H₁₅NO₄
• Molecular Weight: 285.29
• Mol File: 71115-83-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: FA-PHE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FA-PHE-OH(71115-83-8)
• EPA Substance Registry System: FA-PHE-OH(71115-83-8)

Safety Data

• Hazardous Substances Data: 71115-83-8(Hazardous Substances Data)

Usage

Description

FA-PHE-OH, also known as 2-Furanacryloyl-L-phenylalanine, is a chemical compound derived from the combination of furanacryloyl and L-phenylalanine. It is characterized by its unique chemical structure and properties, which make it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
FA-PHE-OH is used as a detection agent for angiotensin-converting enzyme (ACE) inhibitors. It is particularly useful in the development and testing of new drugs that target ACE, which plays a crucial role in regulating blood pressure and is a common target for hypertension treatments. By using FA-PHE-OH on 96 well plates, researchers can efficiently screen and identify potential ACE inhibitors, accelerating the drug discovery process.

Upstream product

• 26390-02-3 N-<3-(2-furyl)acryloyl>-Phe-Phe-NH2 
• 65376-39-8 N-[3-(2-furyl)acryloyl]-phenylalanine methyl ester 
• 20689-54-7 3-furanylacryloyl chloride 
• 539-47-9 3-(2-furyl)acrylic acid 
• 90846-39-2 N-<3-(2-furyl)acryloyl>-Phe-Gly-NH2 
• 598-41-4 H-Gly-NH₂ 
• 5241-58-7 L-Phenylalanine amide 
• 687-51-4 H-L-Leu-NH₂ 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 1668-10-6 glycinamide hydrochloride 

Downstream Products

• 83661-95-4 3-(2-furyl)acryloylglycyl-L-phenylalanine-L-phenylalanine 
• 1236954-99-6 FA-Phe-His 
• 93936-28-8 FA-Phe-Val 
• 1236954-97-4 FA-Phe-Met 
• 1236954-94-1 FA-Phe-Ile 
• 1236954-92-9 C₂₇H₂₅N₃O₅ 
• 71067-15-7 C₂₀H₁₈N₂O₆ 

Relevant articles and documents

The Effect of Pressure on Protease-catalysed Peptide Formation

Peptide formation from an N-acyl amino acid ester and an amino acid amide using carboxypeptidase Y as a catalyst was shown to be considerably influenced by applying high pressure; at 150 MPa the peptide yield was almost five-fold higher than that at 0.1 MPa when PheNH2 was used as the nucleophile.

Synthesis of some amino acid and peptide conjugates and their evaluation as potential anti-allergic and anti-inflammatory agents

ANEW series of N-3-(2-furanyl) acryloyl, N-3-(5-methyl)-2-(furanyl)-acryoyl amino acids, peptide and piprazines amids, were structurally designed and synthesized. About 23 compounds (5a-w) were synthesized and their anti-allergic and anti-inflamatory acti

Action of Serine Carboxypeptidases on Endopeptidase Substrates, N-Acyldipeptideamides

Action patterns of two serine carboxypeptidases, one from yeast (Y) and the other from wheat bran (W), on N--(Fua-)-dipeptideamide substrates were examined by HPLC and amino acid analysis.In the reaction of the wheat enzyme the substrates were hydrolyzed to Fua-amino acid and no sufficient amount of Fua-dipeptides were detected on HPLC in the product mixtures.Very few or no free amino acids were observed by amino acid analysis.This indicates that the wheat enzyme exhibited carboxamidopeptidase activity on these substrates.On the contrary, carboxypeptidase Y gave Fua-amino acids and Fua-dipeptides as products, depending on the structure of the substrates.Accordingly, liberations of free amino acids were detected in some cases.This result shows that the yeast enzyme acts on some of the substrates in a two step manner: First by amidase and second by a carboxypeptidase activity.Based on these results the substrate binding mechanisms of these enzymes are discussed.