71079-19-1

Basic information

• Product Name: Timegadine
• Synonyms: Timegadine;N-Cyclohexyl-N'-(2-methyl-4-quinolyl)-N''-(2-thiazolyl)guanidine;N-Cyclohexyl-N''-(2-methylquinol-4-yl)-N'-2-thiazolylguanidine
• CAS NO: 71079-19-1
• Molecular Formula: C₂₀H₂₃N₅S
• Molecular Weight: 365.49
• EINECS: 275-184-0
• Mol File: 71079-19-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 537.6 °C at 760 mmHg
• Flash Point: 278.9 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 1.25E-11mmHg at 25°C
• Refractive Index: 1.701
• PKA: 7.71±0.50(Predicted)
• CAS DataBase Reference: Timegadine(CAS DataBase Reference)
• NIST Chemistry Reference: Timegadine(71079-19-1)
• EPA Substance Registry System: Timegadine(71079-19-1)

Safety Data

• Hazardous Substances Data: 71079-19-1(Hazardous Substances Data)

Usage

Description

Timegadine is an anti-inflammatory drug that possesses potent prostaglandin synthetase inhibitory properties. It effectively inhibits cyclo-oxygenase (COX) and lipo-oxygenase, making it a valuable compound in the realm of pharmaceuticals for managing inflammation and related conditions.

Uses

Used in Pharmaceutical Industry:
Timegadine is used as an anti-inflammatory agent for its ability to inhibit prostaglandin synthetase, COX, and lipo-oxygenase. This makes it a suitable candidate for the treatment of various inflammation-related conditions, providing relief and managing the symptoms effectively.
Used in Pain Management:
In the field of pain management, Timegadine is utilized as a therapeutic agent to alleviate pain by reducing the production of prostaglandins, which are known to play a significant role in the sensation of pain and inflammation.
Used in Inflammatory Disease Treatment:
Timegadine is also used in the treatment of various inflammatory diseases, where its inhibitory effects on key enzymes involved in the inflammatory process can help in reducing inflammation and managing the disease progression.

InChI:InChI=1/C20H23N5S/c1-14-13-18(16-9-5-6-10-17(16)22-14)24-19(25-20-21-11-12-26-20)23-15-7-3-2-4-8-15/h5-6,9-13,15H,2-4,7-8H2,1H3,(H2,21,22,23,24,25)

Upstream product

• 71070-70-7 N-cyclohexyl-N'-4-(2-methylquinolyl)urea 
• 96-50-4 2-thiazolylamine 
• 71079-18-0 N¹-cyclohexyl-N²-(2-methyl-4-quinolyl)carbodiimide 

Relevant articles and documents

Basic Antiinflammatory Compounds. N,N',N''-Trisubstituted Guanidines

A variety of basic N,N',N''-trisubstituted guanidines was prepared and tested for antiinflammatory activity.Compounds with a thiazoylguanidine moiety linked to the 4 position of the 2-methylquinoline ring exhibited fairly high antiinflammatory activity.Optimal activity was associated with the presence of N-cycloalkyl substituents on N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine.Pharmalogical data on N-cyclohexyl-N''-4-(2-methylquinolyl)-N'-2-thiazolylguanidine (SR 1368, 44) are presented and discussed.