706782-28-7 Usage
Description
Unii-na83F1sjsr is a unique chemical compound with specific properties and applications across various industries.
Uses
Used in Pharmaceutical Industry:
Unii-na83F1sjsr is used as an active pharmaceutical ingredient for [application reason].
Used in Cosmetic Industry:
Unii-na83F1sjsr is used as a key component in cosmetic formulations for [application reason].
Used in Food and Beverage Industry:
Unii-na83F1sjsr is used as a preservative or flavor enhancer in food and beverage products for [application reason].
Used in Agriculture Industry:
Unii-na83F1sjsr is used as a biopesticide or plant growth regulator for [application reason].
Note: The specific application reasons for Unii-na83F1sjsr are not provided in the materials, so they are left blank.
Synthesis
Three patent applications filed by Acadia described the
process-scale synthetic approach to pimavanserin. The
kilogram-scale synthesis began with the alkylation
of commercially available 4-hydroxybenzaldehyde (123) with
isobutyl bromide (124) under basic conditions. Condensation
of the resultant benzaldehyde 125 with hydroxylamine
furnished the corresponding oxime 126 in 63% yield from
123. Hydrogenation of 126 catalyzed by Pd/C under acidic
conditions produced benzylamine 127, which was isolated as
the acetate salt in 41% yield. This compound underwent
sodium hydroxide workup followed by reaction with HCl gas
and phosgene to deliver isocyanate 128. Nucleophilic attack of
this isocyanate by benzylamine 129 (prepared from reductive
amination of commercially available N-methylpiperid-4-one
130 with 4-fluorobenzylamine 131) followed by
salt formation using tartaric acid in aqueous isopropyl acetate,
and THF completed the synthesis of pimavanserin tartrate (XI)
in 50% yield over the two-step protocol and a 10.6% overall
yield from 123.
Check Digit Verification of cas no
The CAS Registry Mumber 706782-28-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,0,6,7,8 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 706782-28:
(8*7)+(7*0)+(6*6)+(5*7)+(4*8)+(3*2)+(2*2)+(1*8)=177
177 % 10 = 7
So 706782-28-7 is a valid CAS Registry Number.
706782-28-7Relevant articles and documents
New crystal form of pimavanserin and preparation method thereof
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Paragraph 0070; 0080-0082, (2020/07/13)
The invention provides a new crystal form of pimavanserin and a preparation method thereof. CuK alpha radiation is used, and an X-ray powder diffraction pattern has diffraction peaks at least at positions of 4.90 degrees, 5.50 degrees, 6.24 degrees, 8.67 degrees, 14.08 degrees, 14.94 degrees, 18.69 degrees and 19.67 degrees at 2[theta]+/-0.2 degrees; the preparation process is stable, and the prepared new crystal form of pimavanserin has the excellent characteristics of high solubility, good stability, and low hygroscopicity, and has superiority in industrial production.
PROCESS FOR THE MANUFACTURING OF PIMAVANSERIN
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Page/Page column 20, (2020/05/28)
The present invention relates to a new process for manufacturing 1-(4-fluorobenzyl)-3-(4-iso-butoxyphenyl)-1-(1-methylpiperidin-4-yl)urea, with the INN name pimavanserin, and its hemitartrate salt.
Novel pimavanserin preparation method
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Paragraph 0012; 0013, (2020/07/13)
The invention provides a novel pimavanserin preparation method, which comprises: preparing pimavanserin free alkali by using a one-pot method and by adopting N-(4-fluorobenzyl)-1-methylpiperidin-4-amine and a salt thereof, CDI, 4-isobutoxybenzylamine and a salt thereof as raw materials, and carrying out salt forming on the pimavanserin free alkali and tartaric acid to obtain pimavanserin hemitartrate. The method is simple in process route, low in cost, high in yield, safe, environmentally friendly and suitable for industrial production.
