703-56-0

Basic information

• Product Name: 3-PHENYL-2-OXAZOLIDINONE
• Synonyms: 3-PHENYL-2-OXAZOLIDINONE;TIMTEC-BB SBB008146;3-Phenyl-1,3-oxazolidin-2-one;3-Phenyloxazolidine-2-one;3-phenyloxazolidin-2-one
• CAS NO: 703-56-0
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: 826-136-8
• Mol File: 703-56-0.mol
• Article Data: 55

Chemical Properties

• Melting Point: 120-122°C
• Boiling Point: 251.6°C at 760 mmHg
• Flash Point: 106°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.0203mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Very Slightly)
• BRN: 139712
• CAS DataBase Reference: 3-PHENYL-2-OXAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-2-OXAZOLIDINONE(703-56-0)
• EPA Substance Registry System: 3-PHENYL-2-OXAZOLIDINONE(703-56-0)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 703-56-0(Hazardous Substances Data)

Usage

Description

3-Phenyl-2-oxazolidinone, with the chemical abstracts service number 703-56-0, is a heterocyclic compound that features a five-membered oxazolidinone ring fused with a phenyl group. This unique structure endows it with potential biological activities and makes it a compound of interest in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
3-Phenyl-2-oxazolidinone is used as a therapeutic agent for the treatment of type 2 diabetes. Its structure allows it to potentially modulate key biological targets involved in glucose metabolism and insulin sensitivity, offering a new avenue for managing this prevalent metabolic disorder.
Given the provided information, there is only one application mentioned for 3-Phenyl-2-oxazolidinone, which is its use in the pharmaceutical industry for treating type 2 diabetes. If additional applications or industries were to be identified in the future, they could be listed separately following the format provided.

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 2977, 1986 DOI: 10.1021/jo00365a024

InChI:InChI=1/C9H9NO2/c11-9-10(6-7-12-9)8-4-2-1-3-5-8/h1-5H,6-7H2

Upstream product

• 75-21-8 oxirane 
• 71-91-0 tetraethylammonium bromide 
• 103-71-9 phenyl isocyanate 
• 935-06-8 N-(2-chloroethyl)aniline 
• 501-53-1 benzyl chloroformate 
• 75-44-5 phosgene 
• 122-98-5 2-Anilinoethanol 
• 542-52-9 Dibutyl carbonate 
• 705-65-7 [1,3]dithiolan-2-ylidenephenylamine 
• 497-25-6 dimethylenecyclourethane 
• 107-07-3 2-chloro-ethanol 
• 3741-38-6 ethylene sulfite 
• 5679-75-4 phenyl-(3-phenyl-oxazolidin-2-ylidene)-amine 
• 96-49-1 [1,3]-dioxolan-2-one 

Downstream Products

• 89338-08-9 phenyloxazolone 
• 122-98-5 2-Anilinoethanol 
• 21089-36-1 3-phenylthiazolidin-2-one 
• 5888-88-0 3-phenyl-1,3-oxazolidin-2-thione 
• 1313524-78-5 C₁₅H₁₁F₂NO₂ 
• 1075-76-9 N-cyanoethylaniline 
• 199387-45-6 4-phenyl-3-((E)-3-phenylacryloyl)oxazolidin-2-one 
• 5319-52-8 N-[2-(piperidin-1-yl)ethyl]aniline 
• 36716-44-6 N-[2-(pyrrolidin-1-yl)ethyl]aniline 
• 2346-26-1 2,4-oxazolidinedione 
• 935-06-8 N-(2-chloroethyl)aniline 

Relevant articles and documents

The Synthesis of 3-Aryl-2-oxazolidinones from CO2, Ethylene Oxide, and Anilines Under Mild Conditions Using PVA-DFNT/Ni

Abstract: A novel nanocatalyst design using nanomaterials through active-zone crystallisation was proposed. The hydrothermal crystallisation of amorphous dendritic fibrous nano-titanium dioxide with Ni (DFNT/Ni) sites was determined to be the main step in producing extremely active dendritic DFNT/Ni zones, which in turn dramatically enhanced their catalytic activities. DFNT/Ni was then combined with polyvinyl alcohol (PVA) by using a traditional individual-nozzle electrospinning method, and the resulting material was named PVA-DFNT/Ni. This method was utilised to produce 3-aryl-2-oxazolidinones from ethylene oxide, CO2, and anilines. The prepared catalytic apparatus was eco-friendly and had the advantages of high catalytic activity, ability to improve the reaction mixture, and reusability without a considerable decrease in efficiency. It is extracted in the straight and adoptive chemical fixation of flue-gas CO2 obtained from industrial emissions, thereby achieving high degrees of CO2 absorption and conversion. Graphic Abstract: [Figure not available: see fulltext.].

Nickel-catalyzed N-arylation of amines with arylboronic acids under open air

In this study, a well-defined, novel NHC-Ni complex was developed and used to catalyze the N-arylation of alkyl- and arylamines with arylboronic acids in a rare version of Chan-Lam coupling. Although the same coupling using copper catalysts has been widely studied, the nickel-catalyzed version is rare and normally requires 10–20 mol% catalyst loading. This novel NHC-Ni complex in combination with 4,4′-dimethyl-2,2′-bipyridine, however, proved to be an effective catalyst that lowered the required catalyst loading to only 2.0 mol%.

Method for synthesizing N - aryl oxazolidine -2 - ketone compound by ionic liquid catalysis

The invention discloses a method for catalytic synthesis of a N-aryloxazolane-2-one compound or a chiral N-aryloxazolane-2-one compound from an ionic liquid. The process of the preparation method is as follows: a catalytic amount of ionic liquid is added