70254-52-3Relevant articles and documents
A 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester preparation method (by machine translation)
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Paragraph 0021; 0022, (2017/02/09)
The invention discloses a 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester preparation method, the method is 3 - amino-crotonic acid ethyl ester with malonic acid diethyl ester in ethanol sodium under the action of the condensation and dick graceful esterclaye woods ester gram one after the condensation reaction to produce the product 2, 4 - dihydroxy - 6 - methyl-nicotinic acid ethyl ester. The method of the invention condensation and two-step responds the Claye woods ester gramdick graceful ester condensation reactions are carried out in the same system, significantly shortens the reaction time, greatly reduces the production cost, simple preparation method of the present invention, the reaction system is green, and the reaction conditions are not severe, the obtained product purity is up to 99% or more, and the yield can reach 80% or more, so it is suitable for industrial large-scale production. (by machine translation)