70030-11-4

Basic information

• Product Name: 3-hydroxyphenazepam
• Synonyms: 3-hydroxyphenazepam;3-Hydroxyphenazepam ada@tuskwei.com whatsapp;7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
• CAS NO: 70030-11-4
• Molecular Formula: C₁₅H₁₀BrClN₂O₂
• Molecular Weight: 365.613
• Product Categories: 3-Hydroxyphenazepam ada@tuskwei.com whatsapp;+8618031153937
• Mol File: 70030-11-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 544.5°C at 760 mmHg
• Flash Point: 283.1°C
• Appearance: /
• Density: 1.7g/cm³
• Vapor Pressure: 1.09E-12mmHg at 25°C
• Refractive Index: 1.712
• Storage Temp.: refrigerate for prolonged storage
• CAS DataBase Reference: 3-hydroxyphenazepam(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxyphenazepam(70030-11-4)
• EPA Substance Registry System: 3-hydroxyphenazepam(70030-11-4)

Safety Data

• Hazardous Substances Data: 70030-11-4(Hazardous Substances Data)

Usage

Description

3-Hydroxyphenazepam is an active metabolite of the novel psychoactive benzodiazepine phenazepam, which emerged in online drug markets in late 2011. It is a GABAA receptor agonist with diminished myorelaxant properties but is about equivalent in most other regards. Despite being a controlled substance in Europe, North America, and many countries in Asia, phenazepam has been encountered in the form of LSD mimic blotters and as counterfeit diazepam. This certified Snap-N-Spike(R) solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology, and urine drug testing.

Uses

Used in Neurological Disorders Treatment:
3-Hydroxyphenazepam is used as a therapeutic agent for neurological disorders such as epilepsy, alcohol withdrawal, and insomnia. It modulates the GABAA receptor, providing relief and managing the symptoms of these conditions.
Used in Premedication before Surgery:
3-Hydroxyphenazepam is used as a premedication agent before surgery, as it augments the effects of anesthetics and reduces anxiety in patients. This helps in ensuring a smoother and more comfortable surgical experience.
Used in Forensic Analysis:
3-Hydroxyphenazepam is used as a starting material in calibrators and controls for various GC/MS or LC/MS applications in forensic analysis. This aids in the accurate identification and quantification of the compound in samples.
Used in Clinical Toxicology:
3-Hydroxyphenazepam is used in clinical toxicology for the assessment and monitoring of drug levels in patients, helping in the diagnosis and management of potential drug toxicity.
Used in Urine Drug Testing:
3-Hydroxyphenazepam is used in urine drug testing to detect the presence of the compound in individuals, which can be crucial for monitoring drug abuse, compliance with treatment, or workplace drug testing programs.

benefits

3-Hydroxyphenazepam is a potent and effective benzodiazepine that works in the central nervous system. It provides calming effects by making the nerves in the brain less sensitive to stimulation. Benefits:Treats insomnia and other sleep disordersDoes not violate natural sleep architectureInstant relief of tension and mental stressReduces pain and helps you relaxDoes not have myorelaxant side effectsHypnotic and anticonvulsant effects

Biological Activity

Phenazepam is an anxiolytic and hypnotic sedative. 3-hydroxy Phenazepam is a major metabolite of phenazepam. There are significant differences in the rate of phenazepam metabolism in different species, so that 3-hydroxy phenazepam can be detected shortly after oral administration of the parent compound in cats, rats, and dogs but not in humans. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

InChI:InChI=1/C15H10BrClN2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

Upstream product

• 51753-57-2 phenazepam 

Downstream Products

• 129166-25-2 7-bromo-5-(o-chlorophenyl)-1-methyl-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one 
• 1381777-43-0 7-bromo-5-(2-chlorophenyl)-1-hexyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine-2,3-dione 
• 1228344-13-5 7-bromo-1-cetyl-5-(2-chlorophenyl)-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine-2,3-dione 
• 1228344-15-7 7-bromo-1-cetyl-5-(2-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one 
• 1228344-12-4 7-bromo-5-(2-chlorophenyl)-1-dodecyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine-2,3-dione 
• 1228344-14-6 7-bromo-5-(2-chlorophenyl)-1-dodecyl-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one 
• 375841-88-6 6-bromo-4-(2-chloro-phenyl)-quinazoline-2-carbaldehyde 
• 60773-49-1 (2-amino-5-bromophenyl)(2-chlorophenyl)methanone 

Relevant articles and documents

Oxidation of nitrogen-containing heterocycles using biocatalysts

A method for stereospecific hydroxylation of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones using free and immobilized cells of actinomycetcs as biocatalysts was developed. The hydroxylation under the action of yeast results in the formation of racemates. Actinomyces do not hydroxylate quinazolinones, quinoxalinones, and tetrahydro-1,5-benzodiazepin-2-ones; derivatives of 1,2,3,4-tetrahydro-1,5-benzodiazocin-2-ones are transformed into 2-[N-(3-acetylaminopropionyl)amino]benzophenones.

METABOLISM OF PHENAZEPAM IN THE RAT ORGANISM

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