70-16-6

Basic information

• Product Name: THIAMINE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB001377;THIAMIO HYDROCHLORIDUM;THIAMIN HYDROCHLORIDE;THIAMINIUM CHLORIDE HYDROCHLORIDE;THIAMINIUM DICHLORIDE;THIAMINE;THIAMINE CHLORIDE HYDROCHLORIDE;THIAMINE HCL
• CAS NO: 70-16-6
• Molecular Formula: C₁₂H₁₇N₄OS
• Molecular Weight: 337.27
• EINECS: 200-641-8
• Mol File: 70-16-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 250 °C (dec.)(lit.)
• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: 0.1 g/mL at 20 °C, clear, colorless
• CAS DataBase Reference: THIAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: THIAMINE HYDROCHLORIDE(70-16-6)
• EPA Substance Registry System: THIAMINE HYDROCHLORIDE(70-16-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 1
• RTECS: XI7350000
• F: 3-8-10
• Hazardous Substances Data: 70-16-6(Hazardous Substances Data)

Usage

Description

THIAMINE HYDROCHLORIDE, also known as thiamin chloride hydrochloride, is a colorless crystalline compound that is very soluble in water, making it a suitable form for parenteral administration. It is soluble in methanol and glycerol but practically insoluble in acetone, ether, chloroform, and benzene. THIAMINE HYDROCHLORIDE is a derivative of thiamin, which is an essential nutrient for the human body, playing a crucial role in energy metabolism and nerve function.

Uses

Used in Food/Feed Supplementation:
THIAMINE HYDROCHLORIDE is used as a nutrient supplement for the enhancement of food and feed products. It helps to ensure that the essential nutrient thiamin is present in adequate amounts, contributing to the overall health and well-being of consumers.
Used in Pharmaceutical Preparations:
THIAMINE HYDROCHLORIDE is used as an active ingredient in dry pharmaceutical formulations. Its high solubility in water makes it an ideal choice for the development of medications that require easy absorption and rapid onset of action.
Used in Quantitative Determination:
The yellow biologically inactive product, thiochrome, derived from the oxidation of free thiamin, exhibits strong blue fluorescence. THIAMINE HYDROCHLORIDE can be used as a reference compound for the quantitative determination of thiamin in various samples, ensuring accurate measurement and assessment of thiamin levels.
Used in Metabolic Processes:
The metabolically active form of THIAMINE HYDROCHLORIDE is thiamin diphosphate, also known as thiamin pyrophosphate. It plays a vital role in energy metabolism and nerve function, making it an essential component in the maintenance of overall health and proper bodily function.

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 7732-18-5 water 
• 2281-20-1 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-methyldisulfanyl-but-1-en-t-yl)-formamide 
• 64-19-7 acetic acid 
• 82205-83-2 lactylthiamin 

Downstream Products

• 1886-29-9 N-(2-methyl-4-amino-5-pyrimidinyl)methylaniline 
• 2908-73-8 (4-amino-2-methylpyrimidin-5-yl)methanesulfonic acid 
• 299-35-4 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazole-2-thione 
• 614-05-1 oxythiamine chloride hydrochloride 
• 51706-91-3 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-bromo-ethyl)-4-methyl-thiazolium; bromide hydrobromide 
• 117026-52-5 5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; bis-(4-phenylazo-benzenesulfonate ) 
• 123965-06-0 5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium; [4-(4-dimethylamino-phenylazo)-benzenesulfonate ] 
• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 73-67-6 2-methyl-4-amino-5-hydroxymethylpyrimidine 
• 95-02-3 5-(aminomethyl)-2-methylpyrimidin-4-amine 
• 15678-01-0 5-hydroxy-3-mercapto-2-pentanone 
• 532-43-4 vitamin B₁ mononitrate 
• 1351982-04-1 4-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)benzoic acid 
• 1351982-03-0 ethyl 4-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methoxy)benzoate 

Relevant articles and documents

Secondary β-Deuterium Isotope Effects in Decarboxylation and Elimination Reactions of α-Lactylthiamin: Intrinsic Isotope Effects of Pyruvate Decarboxylase

The reactions of the adduct of pyruvate and thiamin, lactylthiamin (2-(lact-2-yl)thiamin), are accurate nonenzymic models for reactions of intermediates formed during catalysis by pyruvate decarboxylase.The enzymatic reaction generates lactylthiamin diphosphate from pyruvate and thiamin diphosphate. β-Deuterium isotope effects were determined for the nonenzymic reactions, and the results were related to isotope effects on the enzymic reaction. 2-(Lact-2-yl-β-d3)thiamin was prepared by condensation of methyl pyruvate-d3 with thiamin followed by hydrolysis.The isotope effect for decarboxylation of lactylthiamin in acidic solution at 25 deg C (kH3/kD3) is 1.09 (standard deviation (SD) 0.015) in pH 3.8, 0.5 M sodium acetate: isotope effect = 1.095 (SD 0.014) in 0.001 M HCl.The reaction was also studied using 38 percent ethanolic aqueous sodium acetate (pH 3.8 before mixing with ethanol) since the enzymic sites are less polar than water and the reaction is significantly accelerated by the cosolvent.The isotope effect is within statistical range of that for the reaction in water, 1.105 (SD 0.016), indicating that acceleration by the solvent does not change the extent of hyperconjugative stabilization of the transition state relative to the ground state.The isotope effect for the base-catalysed elimination of pyruvate from lactylthiamin was determined from kinetic studies by using multiwavelength analysis for reactions in pH 11 sodium carbonate solution.The isotope effect (kH3/kD3) is 1.12 (SD 0.01), which is slightly higher than the effect on decarboxylation.The isotope effets indicate that there is considerable interaction between the methyl protons of the lactyl group and the incipient electron-rich center which develops as either carbon dioxide or pyruvate is lost.The isotope effects are slightly larger than the effect reported for the catalytic rate in pyruvate decarboxylase with pyruvate-d3 as a substrate and inverse to the effects for V/K terms.This suggests that the enzymic reaction is subject to rate-limiting processes which are less isotope sensitive but that the reactions of enzyme-bound lactylthiamin diphosphate probably account for most of the observed effect on kcat in the enzymic reaction.