6961-60-0 Usage
Description
9-cycloheptyl-9H-purin-6-amine, also known as CYC116, is a chemical compound belonging to the purine family. It is a potent and selective inhibitor of the aurora kinases, which are essential in regulating cell division and proliferation. 9-cycloheptyl-9H-purin-6-amine has demonstrated promising anticancer activity, especially in the treatment of solid tumors and hematological malignancies. Additionally, it has shown potential in overcoming drug resistance and enhancing the effectiveness of chemotherapy.
Uses
Used in Oncology:
9-cycloheptyl-9H-purin-6-amine is used as an anticancer agent for its ability to inhibit aurora kinases, which are involved in the regulation of cell division and proliferation. This makes it a promising candidate for the treatment of various types of cancer, particularly solid tumors and hematological malignancies.
Used in Overcoming Drug Resistance:
9-cycloheptyl-9H-purin-6-amine is used to address drug resistance in cancer treatment. Its ability to inhibit aurora kinases can help overcome resistance to conventional chemotherapy, thereby enhancing the effectiveness of treatment for patients with cancer.
Used in Enhancing Chemotherapy Effectiveness:
9-cycloheptyl-9H-purin-6-amine is utilized to improve the efficacy of chemotherapy. By targeting aurora kinases, it can enhance the effectiveness of chemotherapeutic drugs, making it a valuable addition to cancer treatment protocols.
Further research and clinical trials are ongoing to explore the therapeutic potential of 9-cycloheptyl-9H-purin-6-amine in the treatment of various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 6961-60-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,6 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6961-60:
(6*6)+(5*9)+(4*6)+(3*1)+(2*6)+(1*0)=120
120 % 10 = 0
So 6961-60-0 is a valid CAS Registry Number.
6961-60-0Relevant articles and documents
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands
Lambertucci, Catia,Antonini, Ippolito,Buccioni, Michela,Dal Ben, Diego,Kachare, Dhuldeo D.,Volpini, Rosaria,Klotz, Karl-Norbert,Cristalli, Gloria
experimental part, p. 2812 - 2822 (2009/09/08)
Importance of making available selective adenosine receptor antagonists is boosted by recent findings of adenosine involvement in many CNS dysfunctions. In the present work a series of 8-bromo-9-alkyl adenines are prepared and fully characterized in radio
