69605-90-9Relevant articles and documents
Experimental and density functional theory studies on hydroxymethylation of phenylboronic acids with paraformaldehyde over a Rh-PPh3 catalyst
Wang, Kuan,Lan, Jie,He, Zhen-Hong,Cao, Zhe,Wang, Weitao,Yang, Yang,Liu, Zhao-Tie
, (2020/12/01)
The synthesis of benzyl alcohols (BAs) is highly vital for their wide applications in organic synthesis and pharmaceuticals. Herein, BAs was efficiently synthesized via hydroxymethylation of phenylboronic acids (PBAs) and paraformaldehyde over a simple Rh-PPh3 catalyst combined with an inorganic base (NaOH). A variety of BAs with the groups of CH3?, CH3O?, Cl?, Br?, and so on were obtained with moderate to good yields, indicating that the protocol had a good universality. Density functional theory (DFT) calculations proposed the Hayashi-type arylation mechanism involved the arylation step of PBA and Rh(OH)(PPh3)2 catalyst to form Rh(I)-bound aryl intermediates and the hydrolysis step of Rh(I)-bound aryl intermediates and HCHO to generate BA product (the rate-determining step). The present route provides a valuable and direct method for the synthesis of BAs and expands the application range of paraformaldehyde.
Compound, pharmaceutically acceptable salt thereof and medical application thereof
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Paragraph 0256-0261, (2020/07/24)
The invention belongs to the field of medicines, and particularly relates to a compound shown as a formula I or medicinal salt thereof. The invention also relates to application of the compound or themedicinal salt thereof in selectively inhibiting LF activity, resisting anthrax toxin toxicity and preventing or treating anthracnose.
Gold catalysis for selective hydrogenation of aldehydes and valorization of bio-based chemical building blocks
Silva, Rerison J. M.,Fiorio, Jhonatan L.,Vidinha, Pedro,Rossi, Liane M.
, p. 2162 - 2169 (2019/12/30)
Gold catalysts are best known for their selectivity in oxidation reactions, however, there is a promising future for gold in selective hydrogenations. Herein, the hydrogenation of several aldehydes and important bio-based chemical building blocks, namely 5-hydroxymethylfurfural (5-HMF), furfural and vanillin, was performed throughout the combination of Au nanoparticles with Lewis bases. The Au-amine ligand (e.g., 2,4,6-trimethylpyridine) catalytic system could reduce the aldehyde carbonyl group selectively, without reducing alkene moieties or opening the furanic ring that occur on most traditional catalysts. Otherwise, the reduction of nitro group is preferential and the catalytic system was used for the synthesis of furfurylamines, important intermediates in the synthesis of different pharmaceuticals (e.g., furosemide), through the selective reductive amination of furfural starting from nitro-compounds. Moreover, a fully heterogeneous gold catalyst embedded in N-doped carbon (Au@N-doped carbon / TiO2) was able to perform these reactions in successive recycles without the addition of ligands, with impact in the development of a continuous flow process for biomass valorization.
