6954-45-6

Basic information

• Product Name: (2-CHLORO-PHENYL)-PHENYL-METHANOL
• Synonyms: (2-CHLORO-PHENYL)-PHENYL-METHANOL;AURORA KA-7059;o-Chlorobenzhydrol;α-(o-Chlorophenyl)benzyl alcohol;α-Phenyl-2-chlorobenzenemethanol;Nsc37575
• CAS NO: 6954-45-6
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.68
• Mol File: 6954-45-6.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 344.1 ºC at 760 mmHg
• Flash Point: 161.9 ºC
• Appearance: /
• Density: 1.221 g/cm³
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2-CHLORO-PHENYL)-PHENYL-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-PHENYL)-PHENYL-METHANOL(6954-45-6)
• EPA Substance Registry System: (2-CHLORO-PHENYL)-PHENYL-METHANOL(6954-45-6)

Safety Data

• Hazardous Substances Data: 6954-45-6(Hazardous Substances Data)

Usage

Description

(2-Chloro-Phenyl)-Phenyl-Methanol is a complex organic compound that is a derivative of benzene and an alcohol. It is characterized by the presence of a phenyl ring with a chlorine substitute at the second carbon atom, to which a phenyl and a methanol group are attached. This gives it the properties of an aromatic compound with hydrophilic characteristics. As a chemical entity, it holds potential for various applications across different industries, with its specific uses and chemical behavior being context-dependent. Careful handling is advised due to the presence of the chlorine group, which may pose certain risks.

Uses

Used in Pharmaceutical Industry:
(2-Chloro-Phenyl)-Phenyl-Methanol is used as an intermediate compound for the synthesis of pharmaceutical products. Its unique structure allows it to be a key component in the development of new drugs, potentially contributing to the treatment of various medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, (2-Chloro-Phenyl)-Phenyl-Methanol is used as a building block for the creation of other complex organic compounds. Its reactivity and structural features make it a valuable precursor in the production of specialty chemicals and materials.
Used in Materials Science:
(2-Chloro-Phenyl)-Phenyl-Methanol is utilized in materials science for the development of novel materials with specific properties. Its incorporation into polymers or other materials can lead to advancements in areas such as electronics, coatings, or adhesives, where its aromatic and hydrophilic nature can enhance performance characteristics.

InChI:InChI=1/C13H11ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9,13,15H

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 694-80-4 2-bromo-1-chlorobenzene 
• 100-52-7 benzaldehyde 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 591-51-5 phenyllithium 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 98-80-6 phenylboronic acid 
• 949-38-2 1-(benzyloxy)-2-chlorobenzene 
• 95-57-8 2-monochlorophenol 
• 100-39-0 benzyl bromide 
• 100-59-4 phenylmagnesium chloride 
• 591-50-4 iodobenzene 
• 100-58-3 phenylmagnesium bromide 
• 934-56-5 trimethyl(phenyl)stannane 

Downstream Products

• 1509911-88-9 (E)-(3-(2-chlorophenyl)prop-1-ene-1,3-diyl)dibenzene 
• 16071-25-3 (S)-2-chlorobenzhydrol 
• 56961-47-8 2-chloro-benzhydryl chloride 
• 29921-41-3 (o-benzyl)chlorobenzene 

Relevant articles and documents

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

4-Methyltetrahydropyran (4-MeTHP): Application as an Organic Reaction Solvent

4-Methyltetrahydropyran (4-MeTHP) is a hydrophobic cyclic ether with potential for industrial applications. We herein report, for the first time, a comprehensive study on the performance of 4-MeTHP as an organic reaction solvent. Its broad application to organic reactions includes radical, Grignard, Wittig, organometallic, halogen-metal exchange, reduction, oxidation, epoxidation, amidation, esterification, metathesis, and other miscellaneous organic reactions. This breadth suggests 4-MeTHP can serve as a substitute for conventional ethers and harmful halogenated solvents. However, 4-MeTHP was found incompatible with strong Lewis acids, and the C?O bond was readily cleaved by treatment with BBr3. Moreover, the radical-based degradation pathways of 4-MeTHP, THP and 2-MeTHF were elucidated on the basis of GC-MS analyses. The data reported herein is anticipated to be useful for a broad range of synthetic chemists, especially industrial process chemists, when selecting the reaction solvent with green chemistry perspectives.

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2.