6936-94-3 Usage
Description
(17beta)-4-nitroestra-1,3,5(10)-triene-3,17-diol, commonly known as 4-nitroestradiol, is a synthetic estrogen compound with a nitro group at the 4 position of the A-ring of the estradiol molecule. It is a unique and potent estrogen receptor modulator that selectively binds to estrogen receptors and regulates gene expression.
Uses
Used in Hormone Replacement Therapy:
4-nitroestradiol is used as a hormone replacement therapy agent for managing symptoms associated with menopause and other conditions related to estrogen deficiency. Its ability to selectively bind to estrogen receptors and regulate gene expression makes it a potential candidate for hormone replacement therapy.
Used in Cancer Treatment:
4-nitroestradiol is used as a cancer treatment agent, particularly against hormone-dependent cancers such as breast and endometrial cancers. It modulates estrogen receptor function and has shown potential in inhibiting tumor growth and progression.
Used in Research:
4-nitroestradiol is used as a research tool for studying estrogen receptor function and the role of estrogen in various physiological processes. Its unique properties make it valuable for understanding the mechanisms of estrogen action and for developing new therapeutic interventions.
Used in Pharmaceutical Industry:
4-nitroestradiol is used as a pharmaceutical compound for developing new drugs and therapies targeting estrogen receptors. Its potential applications in hormone replacement therapy, cancer treatment, and research make it a promising candidate for further development and commercialization.
Note: The use of 4-nitroestradiol also raises some concerns due to its potential toxic effects, and further research is needed to fully understand its mechanisms of action and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 6936-94-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,3 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6936-94:
(6*6)+(5*9)+(4*3)+(3*6)+(2*9)+(1*4)=133
133 % 10 = 3
So 6936-94-3 is a valid CAS Registry Number.
6936-94-3Relevant articles and documents
Bismuth nitrate-induced novel nitration of estradiol: An entry to new anticancer agents
Bandyopadhyay, Debasish,Rivera, Gildardo,Sanchez, Jorge L.,Rivera, Jesse,Granados, Jose C.,Guerrero, Adrian M.,Chang, Fang-Mei,Dearth, Robert K.,Short, John D.,Banik, Bimal K.
, p. 574 - 583 (2014/07/07)
Direct nitration of estradiol was carried out using metal nitrates on solid surfaces under mild condition, and a combination of bismuth nitrate pentahydrate impregnated KSF clay was found to be the best reagent to synthesize 2- and 4-nitroestradiol effectively. Furthermore, various basic side chains were introduced, through O-linker at C-3, to these nitroestradiols. The ability of these derivatives to cause cytotoxicity in Estrogen Receptor (ER)-positive and ER-negative breast cancer cell lines, as well as cancer cell lines of other origins, was examined. Qualitative structure activity relationship (SAR) has also been studied. We found that a basic side chain containing either a piperidine or morpholine ring, when conjugated to 2-nitroestradiol, was particularly effective at causing cytotoxicity in each of the cancer cell lines examined. Surprisingly, this effective cytotoxicity was even seen in ER-negative breast cancer cells.
Preparation of biochemically interesting thioethers of estrogens. II. 2-methoxy-4-(carboxymethylmercapto)estrone-3-methyl ether
Marks,Kubinyi,Hecker
, p. 1215 - 1220 (2007/10/17)
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