6926-45-0Relevant articles and documents
One-pot synthesis of 1,2,3-triazole derivatives of maleopimaric and dihydroquinopimaric acids
Tret’yakova,Salimova,Shakurova,Parfenova,Odinokov
, p. 1701 - 1704 (2017)
Effective one-pot synthesis of 1,2,3-triazole derivatives of maleopimaric and dihydroquinopimaric acids consists in the reaction of diterpene propargyl esters with organic azides generated in situ in the presence of СuI catalyst.
1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: Synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin
Lv, Jing-Song,Peng, Xin-Mei,Kishore, Baathulaa,Zhou, Cheng-He
, p. 308 - 313 (2014)
A series of 1,2,3-triazole-derived naphthalimides as a novel type of potential antimicrobial agents were synthesized and characterized by IR, NMR and HRMS spectra. All the new compounds were screened for their antimicrobial activity against four Gram-positive bacteria, four Gram-negative bacteria and three fungi. Bioactive assay manifested that 3,4-dichlorobenzyl compound 9e and its corresponding hydrochloride 11e showed better anti-Escherichia coli activity than Norfloxacin and Chloromycin. Preliminary research revealed that compound 9e could effectively intercalate into calf thymus DNA to form compound 9e-DNA complex which might block DNA replication and thus exert antimicrobial activities. Human serum albumin could effectively store and carry compound 9e by electrostatic interaction.
Synthesis and rational design of new appended 1,2,3-triazole-uracil ensembles as promising anti-tumor agents via in silico vegfr-2 transferase inhibition
Bhaskar, Kuthati,Hu, Anren,Hung, Sung-Jen,Raju, Atcha Krishnam,Rao, Vankadari Srinivasa,Reddy, Nadipolla Naresh,Reddy, Puchakayala Muralidhar,Rohini, Rondla,Sanjeev, Ananthula,Swamy, Merugu Kumara
, (2021/05/29)
Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles 5a–r were designed and synthesized via the click reaction. The ligands were well characterized using1 H-,13 C-NMR, elemental analysis and ESI-mass spectrometry. The in silico binding propinquities of the ligands were studied sequentially in the active region of VEGFR-2 using the Molegro virtual docker. All the compounds produced remarkable interactions and potentially inhibitory ligands against VEGFR-2 were obtained with high negative binding energies. Drug-likeness was assessed from the ADME properties. Cytotoxicity of the test compounds was measured against HeLa and HUH-7 tumor cells and NIH/3T3 normal cells by MTT assay. Compound 5h showed higher growth inhibition activity than the positive control, 5-fluorouracil (5-FU), against both HeLa and HUH-7 cells with IC50 values of 4.5 and 7.7 μM respectively. Interestingly, the compounds 5a–r did not show any cytotoxicity towards the normal cell lines. The results advance the position of substituted triazoles in the area of drug design with no ambiguity.
Room temperature perylene based columnar liquid crystals as solid-state fluorescent emitters in solution-processable organic light-emitting diodes
Bala, Indu,De, Joydip,Douali, Redouane,Dubey, Deepak Kumar,Gupta, Santosh Prasad,Jou, Jwo-Huei,Pal, Santanu Kumar,Singh, Dharmendra Pratap,Singh, Nitya,Yadav, Rohit Ashok Kumar
supporting information, p. 12485 - 12494 (2020/10/06)
The finding of pure organic emitter materials is the need of the hour for the mass production of cost-effective and metal-free fluorescent organic light-emitting diodes (FOLEDs). In this paper, we report a new series of perylene tetraesters (PTEs) that exhibit the room temperature columnar (Col) mesophase and can act as efficient fluorescent emitter materials in OLEDs. The molecular design involves the attachment of triazole moieties with the PTE discotic coreviaclick chemistry. Triazole groups were chosen as they can improve the electron transport as well as tune the luminescence behavior of discogens. All the PTE derivatives3a-dexhibited ordered columnar rectangular (Colro) mesophases at ambient temperatures suitable for various device applications. The electron mobility of perylene tetraester derivative3awas measured in the mesophase by time of flight (TOF) technique and found to be 0.014 cm2V?1s?1. However, the balanced hole and electron charge transport behaviour was observed in fabricated hole-only and electron-only devices. Taking advantage of both charge transport and the luminescence nature of the PTE derivative in OLEDs, a series of devices were fabricated by utilizing3aas a sole emitter and in the dispersed form at 1, 5 and 8 wt% with the CBP host and at 5 wt% in the SimCP2 host. A significantly high value of the external quantum efficiency (EQE) of 6.5% is obtained in doped devices with the CBP host at 5 wt% dopant (3a) concentration with CIE coordinates of (0.37, 0.53) corresponding to green color. The obtained high EQE value will certainly offer an important step forward to expand the application of smart DLC materials in OLEDs.
