69219-24-5Relevant articles and documents
Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity
Dien, Pham Huu,Nhan, Nguyen Thi,Le Thuy, Hoang Thi,Quang, Dang Ngoc
, p. 2107 - 2111 (2012)
From the ethyl acetate extract of the seeds of Vietnamese Cnidium monnieri L., three coumarins, osthole (1), xanthotoxin (2), imperatorin (3) and a sterol, daucosterol (4) have been purified. Their structures were elucidated by spectroscopic analysis. Furthermore, 8-(3-hidroxy-3-methylbutyl)-7- methoxycoumarin (5) was synthesised from osthole (1) with a good yield (80%). In addition, compound 1 and its synthesis product (5) show moderate and non-selective cytotoxic activities against four cancer cells, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma).
Synthesis and biological evaluation of novel osthol derivatives as potent cytotoxic agents
Farooq, Saleem,Banday, Javid A.,Hussain, Aashiq,Nazir, Momina,Qurishi, Mushtaq A.,Hamid, Abid,Koula, Surrinder
, p. 138 - 149 (2019/06/11)
Background: Natural product, osthol has been found to have important biological and pharmacological roles particularly having inhibitory effect on multiple types of cancer. Objective: The unmet needs in cancer therapeutics make its derivatization an impor