68716-48-3 Usage
Description
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene is an organic compound that serves as an intermediate in the synthesis of various chemical compounds. It is characterized by the presence of a nitro group attached to a benzene ring, which is further substituted with a 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl group. 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NITROBENZENE plays a crucial role in the development of pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Industry:
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene is used as a key intermediate in the synthesis of [(pyrimidoindolyl)phenyl]benzamide derivatives and analogs, which are known as Janus kinase inhibitors. These inhibitors are important in the development of treatments for various diseases, including inflammatory and autoimmune disorders, as they help regulate the immune system by targeting specific enzymes involved in cell signaling pathways.
Used in Organic Synthesis:
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene is also used as a versatile building block in organic synthesis for the preparation of a wide range of chemical compounds. Its unique structure allows for various chemical reactions, such as cross-coupling reactions, which enable the formation of new carbon-carbon or carbon-heteroatom bonds. This makes it a valuable component in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 68716-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,7,1 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 68716-48:
(7*6)+(6*8)+(5*7)+(4*1)+(3*6)+(2*4)+(1*8)=163
163 % 10 = 3
So 68716-48-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H16BNO4/c1-11(2)12(3,4)18-13(17-11)9-6-5-7-10(8-9)14(15)16/h5-8H,1-4H3
68716-48-3Relevant articles and documents
Light- and Manganese-Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time-Scale Revealed by Time-Resolved Spectroscopic Analysis
Firth, James D.,Hammarback, L. Anders,Burden, Thomas J.,Eastwood, Jonathan B.,Donald, James R.,Horbaczewskyj, Chris S.,McRobie, Matthew T.,Tramaseur, Adam,Clark, Ian P.,Towrie, Michael,Robinson, Alan,Krieger, Jean-Philippe,Lynam, Jason M.,Fairlamb, Ian J. S.
supporting information, p. 3979 - 3985 (2021/02/03)
Manganese-mediated borylation of aryl/heteroaryl diazonium salts emerges as a general and versatile synthetic methodology for the synthesis of the corresponding boronate esters. The reaction proved an ideal testing ground for delineating the Mn species responsible for the photochemical reaction processes, that is, involving either Mn radical or Mn cationic species, which is dependent on the presence of a suitably strong oxidant. Our findings are important for a plethora of processes employing Mn-containing carbonyl species as initiators and/or catalysts, which have considerable potential in synthetic applications.
NITRATION
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Page/Page column 36; 41; 46; 64; 38; 52; 42; 65, (2020/05/28)
The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromatic ring comprises at least one heteroatom selected from the group consisting of oxygen, sulfur, phosphor, selenium and nitrogen, with a compound of formula (I) wherein Y is selected from the group consisting of hydrogen and nitro.
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 00339, (2020/06/19)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
