68134-81-6

Basic information

• Product Name: Gacyclidine
• Synonyms: Gacyclidine;1-[1-(2-Thienyl)-2α-methylcyclohexan-1α-yl]piperidine;1-[(1R)-1-(2-Thienyl)-2β-methylcyclohexan-1β-yl]piperidine;GK-11;1-[(1S,2R)-2-methyl-1-thiophen-2-ylcyclohexyl]piperidine
• CAS NO: 68134-81-6
• Molecular Formula: C16H25NS
• Molecular Weight: 263.447
• Mol File: 68134-81-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 80-81 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))
• Boiling Point: 352.5 °C at 760 mmHg
• Flash Point: 167 °C
• Appearance: /
• Density: 1.054 g/cm³
• Vapor Pressure: 3.83E-05mmHg at 25°C
• Refractive Index: 1.551
• PKA: 8.56±0.20(Predicted)
• CAS DataBase Reference: Gacyclidine(CAS DataBase Reference)
• NIST Chemistry Reference: Gacyclidine(68134-81-6)
• EPA Substance Registry System: Gacyclidine(68134-81-6)

Safety Data

• Hazardous Substances Data: 68134-81-6(Hazardous Substances Data)

Usage

Description

Gacyclidine, also known as GK-11, is a psychoactive drug and a derivative of phencyclidine (PCP) that functions as a non-competitive NMDA receptor antagonist. It has been explored for its potential in treating Alzheimer’s disease and as an anesthetic. However, its use is restricted due to its potential for causing severe dissociative effects and its toxicity.

Uses

Used in Pharmaceutical Research:
Gacyclidine is used as a research compound for its potential therapeutic applications in treating Alzheimer’s disease and as an anesthetic. Its NMDA receptor antagonistic properties have been of interest in the development of treatments for neurological conditions.
Used in Psychiatric Research:
Gacyclidine is used as a research tool in the study of addiction, depression, and other psychiatric disorders, given its psychoactive properties and its interaction with the NMDA receptor, which is implicated in various mental health conditions.
Used in Anesthesia:
Although its use is limited, Gacyclidine has been studied for its potential as an anesthetic due to its ability to induce a state of dissociative anesthesia.
Used in Controlled Substances:
Due to its potential for abuse and limited therapeutic use, Gacyclidine is considered a controlled substance in some countries, highlighting its use in the regulatory context to prevent misuse and ensure safety in medical applications.

InChI:InChI=1/C16H25NS/c1-14-8-3-4-10-16(14,15-9-7-13-18-15)17-11-5-2-6-12-17/h7,9,13-14H,2-6,8,10-12H2,1H3/t14-,16+/m0/s1