67952-38-9

Basic information

• Product Name: 4-(p-methoxyphenyl)butan-2-ol
• Synonyms: 4-(p-methoxyphenyl)butan-2-ol;1-Methyl-3-(4-methoxyphenyl)propyl alcohol;4-(4-Methoxyphenyl)-2-butanol;4-Methoxy-α-methylbenzene-1-propanol
• CAS NO: 67952-38-9
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24354
• EINECS: 267-891-8
• Mol File: 67952-38-9.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 292.6°C at 760 mmHg
• Flash Point: 122.3°C
• Appearance: /
• Density: 1.017g/cm³
• Vapor Pressure: 0.000831mmHg at 25°C
• Refractive Index: 1.512
• PKA: 15.14±0.20(Predicted)
• CAS DataBase Reference: 4-(p-methoxyphenyl)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(p-methoxyphenyl)butan-2-ol(67952-38-9)
• EPA Substance Registry System: 4-(p-methoxyphenyl)butan-2-ol(67952-38-9)

Safety Data

• Hazardous Substances Data: 67952-38-9(Hazardous Substances Data)

Usage

Description

4-(p-methoxyphenyl)butan-2-ol, with the chemical formula C11H16O2, is a clear, colorless liquid that possesses a slightly sweet odor. It is derived from 4-hydroxybutyrophenone and is commonly produced through the reduction of the corresponding ketone. 4-(p-methoxyphenyl)butan-2-ol is utilized in various applications, including the production of fragrances, flavoring agents in the food industry, and as a precursor in organic chemistry and pharmaceutical synthesis.

Uses

Used in Fragrance Production:
4-(p-methoxyphenyl)butan-2-ol is used as a key ingredient in the production of fragrances for its distinct, slightly sweet scent. It contributes to the creation of various fragrances used in personal care products, perfumes, and other scented items.
Used as a Flavoring Agent in the Food Industry:
In the food industry, 4-(p-methoxyphenyl)butan-2-ol is employed as a flavoring agent to enhance the taste and aroma of various food products. Its sweet odor adds a pleasant flavor profile to a range of consumables.
Used in Pharmaceutical Synthesis:
4-(p-methoxyphenyl)butan-2-ol is utilized in the synthesis of pharmaceuticals, serving as a valuable precursor in the development of new drugs. Its unique chemical structure allows it to be a building block for creating various medicinal compounds.
Used as a Precursor in Organic Chemistry:
In the field of organic chemistry, 4-(p-methoxyphenyl)butan-2-ol is used as a precursor for the synthesis of other organic compounds. Its versatility in chemical reactions makes it a valuable component in the creation of a wide array of chemical products.
Safety Precautions:
It is important to handle 4-(p-methoxyphenyl)butan-2-ol with care, as it can be harmful if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be taken during its production, use, and disposal to minimize potential health risks.

InChI:InChI=1/C11H16O2/c1-9(12)3-4-10-5-7-11(13-2)8-6-10/h5-9,12H,3-4H2,1-2H3

Upstream product

• 104-20-1 4-(4-methoxyphenyl)-2-butanone 
• 69617-84-1 rac-rhododendrol 
• 77-78-1 dimethyl sulfate 
• 3815-30-3 4-(4-methoxyphenyl)-3-buten-2-one 
• 74-88-4 methyl iodide 
• 23304-25-8 p-methoxyphenyldiazomethane 
• 67-63-0 isopropyl alcohol 
• 64-17-5 ethanol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 943-88-4 4-(p-methoxyphenyl)-3-butene-2-one 
• 67-64-1 acetone 
• 55831-55-5 1-isoprenyloxymethyl-4-methoxybenzene 
• 105-13-5 4-Methoxybenzyl alcohol 
• 134747-45-8 4-(4-methoxyphenyl)-3-buten-2-ol 

Downstream Products

• 10528-67-3 4-cyclohexyl-2-butanol 
• 100-09-4 4-methoxybenzoic acid 
• 104-20-1 4-(4-methoxyphenyl)-2-butanone 
• 152339-86-1 (S)-4-(4′-methoxyphenyl)-2-butanol 
• 39516-05-7 (R)-4-(4′-methoxyphenyl)-2-butanol 
• 39831-53-3 1-(but-2-en-1-yl)-4-methoxybenzene 
• 20574-98-5 4-(p-methoxyphenyl)but-1-ene 
• 126521-63-9 4-(4-methoxyphenyl)butan-2-yl 4-methylbenzenesulfonate 
• 344791-87-3 (rac)-4-(3-bromobutyl)-1-methoxybenzene 
• 1383841-51-7 (rac)-1-methoxy-4-(3-phenylbutyl)benzene 
• 1383841-50-6 1-(3-iodo-butyl)-4-methoxy-benzene 
• 1338073-35-0 2-(4-(4-methoxyphenyl)butan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

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Interrupting the Barton?McCombie reaction: Aqueous deoxygenative trifluoromethylation of o-alkyl thiocarbonates

The site-selective trifluoromethylation of aliphatic systems remains an important challenge. This work describes a light-driven, copper-mediated trifluoromethylation of O-alkyl thiocarbonates. The reaction provides broad functional group tolerance (e.g., alkyne, alkene, phenol, free alcohol, electron-rich and -deficient arenes), thereby offering orthogonality and practicality for trifluoromethylation. A radical organometallic mechanism is proposed.

Selective Cross-Dehydrogenative C(sp3)-H Arylation with Arenes

Selective C(sp3)-C(sp2) bond construction is of central interest in chemical synthesis. Despite the success of classic cross-coupling reactions, the cross-dehydrogenative coupling between inert C(sp3)-H and C(sp2)-H bonds represents an attractive alternative toward new C(sp3)-C(sp2) bonds. Herein, we establish a selective inter-and intramolecular C(sp3)-H arylation of alcohols with nondirected arenes that thereby provides a general pathway to access a wide range of β-arylated alcohols, including tetrahydronaphthalen-2-ols and benzopyran-3-ols, with high to excellent chemo-and regioselectivity.

Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors

Alkyl chlorides are common functional groups in synthetic organic chemistry. However, the engagement of unactivated alkyl chlorides, especially tertiary alkyl chlorides, in transition-metal-catalyzed C-C bond formation remains challenging. Herein, we describe the development of a TiIII-catalyzed radical addition of 2° and 3° alkyl chlorides to electron-deficient alkenes. Mechanistic data are consistent with inner-sphere activation of the C-Cl bond featuring TiIII-mediated Cl atom abstraction. Evidence suggests that the active TiIII catalyst is generated from the TiIV precursor in a Lewis-acid-assisted electron transfer process.