67655-17-8

Basic information

• Product Name: Ethanone, 2-chloro-1-phenyl-2-(phenylthio)-
• CAS NO: 67655-17-8
• Molecular Formula: C14H11ClOS
• Molecular Weight: 262.76
• Mol File: 67655-17-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-chloro-1-phenyl-2-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-phenyl-2-(phenylthio)-(67655-17-8)
• EPA Substance Registry System: Ethanone, 2-chloro-1-phenyl-2-(phenylthio)-(67655-17-8)

Safety Data

• Hazardous Substances Data: 67655-17-8(Hazardous Substances Data)

Upstream product

• 3282-32-4 2-diazo-acetophenone 
• 931-59-9 benzenesulfenyl chloride 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 
• 930-69-8 sodium thiophenolate 
• 532-27-4 1-chloroacetophenone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 89171-35-7 2‐methoxy‐1‐phenyl‐2‐(phenylsulfanyl) ethanone 
• 82834-08-0 Methoxy-phenyl-phenylsulfanyl-acetaldehyde 
• 22805-27-2 ω,ω-bis(phenylthio)acetophenone 
• 137351-38-3 β-keto α-thiophenyl β-phenyl ethyl p-toluene sulfone 
• 16222-10-9 1-phenyl-2-(phenylthio)ethanone 
• 882-33-7 diphenyldisulfane 
• 77128-47-3 (2-Oxo-2-phenyl-1-phenylsulfanyl-ethylsulfanyl)-acetic acid methyl ester 
• 16222-09-6 1,2-diphenyl-2-(phenylthio)ethanone 
• 402717-64-0 phenyl-[6-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-methanone 
• 77128-62-2 2-(benzylthio)-3-phenylbenzo[b]thiophene 
• 77128-63-3 (3-Phenyl-benzo[b]thiophen-2-ylsulfanyl)-acetic acid methyl ester 
• 77128-56-4 ((2R,3R)-3-Hydroxy-3-phenyl-2,3-dihydro-benzo[b]thiophen-2-ylsulfanyl)-acetic acid methyl ester 
• 451-40-1 phenyl benzyl ketone 

Relevant articles and documents

Elaboration of 1-benzoyltetrahydroisoquinoline derivatives employing a Pictet-Spengler cyclization with α-chloro-α-phenylthioketones. Synthesis of O-methylvelucryptine

The reaction of N-tosyl-β-phenethylamines with α-chloro-α-phenylthioketones, leading to 1-benzoyl- and 1-pivaloyl-tetrahydroisoquinolines under modified Pictet-Spengler conditions, is described. The synthesis of O-methylvelucryptine employing this transformation as a key step is reported.

Mono halogenation of β-keto sulfides. Synthesis of β-keto-α-phenylthio p-tolyl sulfones

β-Keto-α-phenylthio p-Tolyl sulfones are obtained from β-keto-alkyl phenyl sulfides by halogenation with NCS followed by treatment with sodium p-toluene sulphinate.

REGIOSPECIFIC SYNTHESIS OF α-(PHENYLTHIO)CYCLOALKENONES AND OF α-PHENYL-α-(PHENYLTHIO)KETONES VIA αα-ADDITION OF PHENYLSULPHENYL CHLORIDE TO α-DIAZOKETONES

Cyclic α-diazoketones react with phenylsulphenyl chloride at room temperature to furnish α-chloro-α-(phenylthio)cycloalkanones which undergo ready dehydrochlorination to α-(phenylthio)cycloalkenones when treated with triethylamine; acyclic, terminal α-diazoketones also furnish α-chloro-α-(phenylthio)adducts which are useful electrophiles in the synthesis of α-phenyl-α-(phenylthio)ketones.