67625-40-5

Basic information

• Product Name: 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;8-METHYLIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER, 95+%;Ethyl 8-methylimidazo[1,2-a]pyridine-2-carboxylate;Zinc02549453;ethyl 8-MethylH-iMidazo[1,2-a]pyridine-2-carboxylate;IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-Methyl-, ethyl ester
• CAS NO: 67625-40-5
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: Heterocycle-Pyridine series
• Mol File: 67625-40-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 68-69℃
• Appearance: /
• Density: 1.19
• Refractive Index: 1.584
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.81±0.50(Predicted)
• CAS DataBase Reference: 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(67625-40-5)
• EPA Substance Registry System: 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(67625-40-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 67625-40-5(Hazardous Substances Data)

Usage

Uses

8-Methylimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

InChI:InChI=1/C11H12N2O2/c1-3-15-11(14)9-7-13-6-4-5-8(2)10(13)12-9/h4-7H,3H2,1-2H3

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 859788-36-6 3-(2-ethoxy-benzoylamino)-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid amide 
• 859788-61-7 3-(2-ethoxy-phenyl)-8-methyl-2H-2,4,4b,9-tetraaza-fluoren-1-one 

Relevant articles and documents

Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding

Efforts towards the development of potential anticancer agents, a new series of imidazo[1,2-a]pyridine-oxadiazole hybrids were synthesized and evaluated for their in vitro anticancer activity against lung cancer (A549) and prostate cancer (PC-3, DU-145) cell lines. Amongst the compounds tested, 6d showed the highest potency on A549 cells with an IC50 value of 2.8 ± 0.02 μM. Flow cytometric analysis of compound 6d treated A549 cells showed apoptosis induction by annexin-v/PI dual staining assay and the effect of 6d on different phases of cell cycle was also analyzed. Target based studies demonstrated the inhibition of tubulin polymerization by 6d at an IC50 value of 3.45 ± 0.51 μM and its effective binding with CT-DNA. Further, the molecular modelling studies revealed that 6d has a prominent binding affinity towards α/β-tubulin receptor with admirable physico-chemical properties.

Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives

Synthesis and primary SAR of a novel series of 2-phenylpyrido[1,2-e]purin- 4(3H)-one derivatives with piperazinyl sulfonamide substituents were described herein. As potential PDE5 inhibitors for erectile dysfunction (ED) treatment, representative compound