67617-97-4

Basic information

• Product Name: N-[(2,5-dimethoxyphenyl)carbamothioyl]benzamide
• Synonyms: N-[(2,5-dimethoxyphenyl)carbamothioyl]benzamide;N-{[(2,5-dimethoxyphenyl)amino]carbonothioyl}benzamide
• CAS NO: 67617-97-4
• Molecular Formula: C₁₆H₁₆N₂O₃S
• Molecular Weight: 316.37484
• Mol File: 67617-97-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[(2,5-dimethoxyphenyl)carbamothioyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(2,5-dimethoxyphenyl)carbamothioyl]benzamide(67617-97-4)
• EPA Substance Registry System: N-[(2,5-dimethoxyphenyl)carbamothioyl]benzamide(67617-97-4)

Safety Data

• Hazardous Substances Data: 67617-97-4(Hazardous Substances Data)

Upstream product

• 532-55-8 Benzoyl isothiocyanate 
• 102-56-7 2,5-dimethoxyaniline 

Downstream Products

• 158632-88-3 (4,5-dihydro-thiazol-2-yl)-(2,5-dimethoxy-phenyl)-amine 
• 1391724-80-3 C₁₇H₁₇FN₂O₄S₂ 
• 1391724-79-0 C₁₇H₁₆Cl₂N₂O₄S₂ 
• 1391724-78-9 C₁₇H₁₈N₂O₄S₂ 
• 1391724-77-8 C₂₁H₂₀N₂O₄S₂ 
• 1391724-76-7 C₁₇H₁₇N₃O₆S₂ 
• 1391724-75-6 C₁₇H₁₇N₃O₆S₂ 
• 1391724-74-5 C₂₆H₃₆N₂O₄S₂ 
• 1391724-73-4 C₁₅H₁₆N₂O₄S₃ 
• 1391724-71-2 C₁₈H₂₀N₂O₅S₂ 
• 1391724-70-1 C₂₁H₂₀N₂O₄S₂ 
• 67617-98-5 (2,5-dimethoxyphenyl)thiourea 
• 864432-02-0 N-(2,5-dimethoxyphenyl)-4-(4-fluorophenyl)thiazol-2-amine 
• 429621-26-1 N-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)thiazol-2-amine 

Relevant articles and documents

Synthesis, SAR and docking studies of substituted aryl phenylthiazolyl phenylcarboxamide as potential protein tyrosine phosphatase 1B (PTP1B) inhibitors

In our continued effort to discover novel PTP1B inhibitor with improved in vivo activity, we attempted to optimize our previously discovered lead compound by replacing the sulfonyl group with benzoyl group to yield compound II. Additional structural modif

Synthesis, Structure-Activity Relationship and Docking Studies of Substituted Aryl Thiazolyl Phenylsulfonamides as Potential Protein Tyrosine Phosphatase1B Inhibitors

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Synthesis and QSAR studies in 2-(N-aryl-N-aroyl)amino-4,5-dihydrothiazole derivatives as potential antithrombotic agents

A series of 2-(N-aryl-N-aroyl)amino-4,5-dihydrothiazole derivatives have been synthesized via cyclocondensation of N-aryl thioureas with 2-bromoethylamine hydrobromide followed by the reaction of the product thus obtained with aroyl chlorides. Title compounds were evaluated for their antithrombotic activity in vivo in mice where one of these compound 29 provided 65% protection as compared to 77% protection offered by the standard Indomethacin. Quantitative Structure-Activity Relationship (QSAR) studies were performed on these compounds using physicochemical (hydrophobic, electronic, steric) parameter as independent and antithrombic activity as dependent parameter, where antithrombotic activity correlated best (r > 0.8) with electronic parameters (F, σ or μ) having high statistical significance > 99.9% (F2,22 > 15.0; F2,22α:0.001 = 11.0) suggesting that hydrophobic, steric and resonance factors are insignificant in this set of molecules for the activity.