675112-70-6

Basic information

• Product Name: 4,4-Difluorocyclohexanamine hydrochloride
• Synonyms: Cyclohexanamine,4,4-difluoro-, hydrochloride (9CI);(4,4-Difluorocyclohexyl)aminehydrochloride;(4,4-Difluorocyclohexyl)ammonium chloride;Cyclohexanamine,4,4-difluoro-, hydrochloride (1:1);1-Amino-4,4-difluorocyclohexane hydrochloride;4,4-Difluorocyclohexylamine HCl
• CAS NO: 675112-70-6
• Molecular Formula: C₆H₁₁F₂N*ClH
• Molecular Weight: 171.616
• Product Categories: Amines
• Mol File: 675112-70-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 295°C
• Boiling Point: 45-47 ºC/12mm
• Flash Point: 67.4oC
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4,4-Difluorocyclohexanamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-Difluorocyclohexanamine hydrochloride(675112-70-6)
• EPA Substance Registry System: 4,4-Difluorocyclohexanamine hydrochloride(675112-70-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 675112-70-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 675112-70-6 differently. You can refer to the following data:
1. Cyclohexyl-substituted pyrrolidinones
2. Cyclohexyl-substituted pyrrolidinones and their use as inhibitors of 11-β-hydroxysteroid dehydrogenase 1.

InChI:InChI=1/C6H11F2N.ClH/c7-6(8)3-1-5(9)2-4-6;/h5H,1-4,9H2;1H

Upstream product

• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 
• 224309-64-2 tert-butyl N-(4-hydroxycyclohexyl)carbamate 
• 675112-67-1 tert-butyl (4,4-difluorocyclohexyl)carbamate 
• 675112-69-3 tert-butyl (4-fluorocyclohex-3-en-1-yl)carbamate 

Downstream Products

• 956382-42-6 4-chloro-N-(4,4-difluoro-cyclohexyl)-butyramide 
• 1159998-38-5 4-nitrophenyl 4,4-difluorocyclohexylcarbamate 
• 1227064-42-7 2,2,2-trichloroethyl (4,4-difluorocyclohexyl)carbamate 
• 1000698-98-5 1,1-difluoro-4-isocyanocyclohexane 
• 956223-39-5 (R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4,4-difluoro-cyclohexyl)-pyrrolidin-2-one 

Relevant articles and documents

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An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically-acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation-induced cancers.

THERAPEUTICALLY ACTIVE COMPOUNDS AND USE THEREOF

Provided are therapeutically active compounds and the use in manufacture of medicaments for treating a cancer characterized by the presence of a mutant allele of IDH1.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.