674-26-0Relevant articles and documents
MANUFACTURING METHOD OF β-HYDROXYLACTONE (METH)ACRYLIC ACID ESTER
-
Paragraph 0045; 0049-0051, (2020/01/23)
PROBLEM TO BE SOLVED: To provide a method capable of manufacturing (meth)acrylic acid ester of β-hydroxylactone at high yield with almost no side reaction. SOLUTION: The problem is solved by a manufacturing method of β-hydroxylactone (meth)acrylic acid ester for providing corresponding (meth)acrylic acid ester by reacting specific β-hydroxylactone (B) and at least one kind of acid anhydride (C) selected from (meth)acrylic acid anhydride (C1) and anhydride of (meth)acrylic acid and carboxylic acid other than the (meth)acrylic acid (C2) in presence of a specific Lewis acid catalyst (A). SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
METHODS OF FORMING DIOL COMPOUNDS
-
Paragraph 0094, (2017/11/06)
Methods of forming a C4 to C7 diol compound, the methods including a first step of reacting a C4 to C7 dicarboxylic acid with hydrogen (H2) gas on a first heterogeneous catalyst at a first temperature and a first pressure to form a C4 to C7 lactone; and a subsequent step of reacting the lactone with hydrogen (H2) gas on a second heterogeneous catalyst at a second temperature and a second pressure, wherein the second temperature is lower than the first temperature. Also disclosed are methods of forming a solvent, the methods including reacting a C4 to C7 dicarboxylic acid with hydrogen (H2) gas on a first heterogeneous catalyst at a first temperature and a first pressure to form a solvent. Further disclosed herein are methods that include reacting mevalonolactone with hydrogen (H2) gas on a second heterogeneous catalyst at a second temperature and a second pressure to form a diol compound.
Quaternary Stereogenic Centers through Enantioselective Heck Arylation of Acyclic Olefins with Aryldiazonium Salts: Application in a Concise Synthesis of (R)-Verapamil
Oliveira, Caio C.,Pfaltz, Andreas,Correia, Carlos Roque Duarte
supporting information, p. 14036 - 14039 (2016/01/25)
We describe herein a highly regio- and enantioselective Pd-catalyzed Heck arylation of unactivated trisubstituted acyclic olefins to provide all-carbon quaternary stereogenic centers. Chiral N,N ligands of the pyrimidine- and pyrazino-oxazoline class were developed for that purpose, providing the desired products in good to high yields with enantiomeric ratios up to >99:1. Both linear and branched substituents on the olefins were well-tolerated. The potential of this new method is demonstrated by the straightforward synthesis of several O-methyl lactols and lactones containing quaternary stereocenters, together with a concise enantioselective total synthesis of the calcium channel blocker verapamil.