67354-61-4

Basic information

• Product Name: N-(PHENYLMETHYL)-L-ASPARTIC ACID
• Synonyms: N-(PHENYLMETHYL)-L-ASPARTIC ACID
• CAS NO: 67354-61-4
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.22522
• Mol File: 67354-61-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 376.7 °C at 760 mmHg
• Flash Point: 181.6 °C
• Appearance: /
• Density: 1.311 g/cm³
• CAS DataBase Reference: N-(PHENYLMETHYL)-L-ASPARTIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-(PHENYLMETHYL)-L-ASPARTIC ACID(67354-61-4)
• EPA Substance Registry System: N-(PHENYLMETHYL)-L-ASPARTIC ACID(67354-61-4)

Safety Data

• Hazardous Substances Data: 67354-61-4(Hazardous Substances Data)

Upstream product

• 56-84-8 L-Aspartic acid 
• 100-52-7 benzaldehyde 
• 110-17-8 (2E)-but-2-enedioic acid 
• 100-46-9 benzylamine 

Downstream Products

• 503027-29-0 N-Benzyl-α-L-aspartyl-glycin-aethylester 
• 117176-17-7 N-benzyl-L-aspartic acid 4-benzyl ester 
• 128576-74-9 (2S,3R)-4-benzyl 1-methyl N-benzyl-N-(9-phenylfluoren-9-yl)-3-benzylaspartate 
• 128576-74-9 (2S,3S)-4-benzyl 1-methyl N-benzyl-N-(9-phenylfluoren-9-yl)-3-benzylaspartate 
• 128576-76-1 (2S,3R)-methyl 3-<(azidocarbonyl)amino>-2--4-phenylbutanoate 
• 128576-77-2 (2S,3R)-methyl 2--4-phenyl-3-ureidobutanoate 
• 128576-70-5 (2S,3R)-1-methyl N-benzyl-N-(9-phenylfluoren-9-yl)-3-benzylaspartate 
• 128576-73-8 (2S)-4-benzyl 1-methyl N-benzyl-N-(9-phenylfluoren-9-yl)aspartate 
• 128576-71-6 (2S)-4-benzyl 1-methyl N-benzyl-N-methylaspartate 
• 128576-72-7 (2S)-4-benzyl 1-methyl N-benzylaspartate 

Relevant articles and documents

Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

Aspartic acid derivatives with branched N-alkyl or N-arylalkyl substituents are valuable precursors to artificial dipeptide sweeteners such as neotame and advantame. The development of a biocatalyst to synthesize these compounds in a single asymmetric step is an as yet unmet challenge. Reported here is an enantioselective biocatalytic synthesis of various difficult N-substituted aspartic acids, including N-(3,3-dimethylbutyl)-l-aspartic acid and N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-l-aspartic acid, precursors to neotame and advantame, respectively, using an engineered variant of ethylenediamine-N,N′-disuccinic acid (EDDS) lyase from Chelativorans sp. BNC1. This engineered C–N lyase (mutant D290M/Y320M) displayed a remarkable 1140-fold increase in activity for the selective hydroamination of fumarate compared to that of the wild-type enzyme. These results present new opportunities to develop practical multienzymatic processes for the more sustainable and step-economic synthesis of an important class of food additives.