670-83-7Relevant articles and documents
Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists
Elliott, Richard L.,Oliver, Robert M.,LaFlamme, Janet A.,Gillaspy, Melissa L.,Hammond, Marlys,Hank, Richard F.,Maurer, Tristan S.,Baker, Demetria L.,DaSilva-Jardine, Paul A.,Stevenson, Ralph W.,Mack, Christine M.,Cassella, James V.
, p. 3593 - 3596 (2003)
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding models, but were also found to have undesired behavioral effects in spontaneous locomotor activity.
Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C–C Coupling and C?N Condensation Cascade Reactions
Fang, Shengyang,Yu, Haihua,Yang, Xicheng,Li, Jianqi,Shao, Liming
supporting information, p. 3312 - 3317 (2019/06/13)
A convenient Ni(II)-catalyzed C?C and C?N cascade coupling reaction was developed to directly access various 2,4-disubstituted imidazoles. The reaction scope covers a variety of aryl and aliphatic substitutions, which demonstrate moderate-to-excellent yie
ZnCl2-Catalyzed [3 + 2] Cycloaddition of Benzimidates and 2 H-Azirines for the Synthesis of Imidazoles
Shi, Shoujie,Xu, Kang,Jiang, Cheng,Ding, Zhenhua
, p. 14791 - 14796 (2018/11/23)
ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reactivity and high functional group tolerance.