666715-90-8

Basic information

• Product Name: Benzoic acid, 4-[(4-nitrophenoxy)sulfonyl]-
• CAS NO: 666715-90-8
• Molecular Formula: C13H9NO7S
• Molecular Weight: 323.283
• Mol File: 666715-90-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(4-nitrophenoxy)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(4-nitrophenoxy)sulfonyl]-(666715-90-8)
• EPA Substance Registry System: Benzoic acid, 4-[(4-nitrophenoxy)sulfonyl]-(666715-90-8)

Safety Data

• Hazardous Substances Data: 666715-90-8(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 10130-89-9 p-carboxyphenylsulfonyl chloride 

Downstream Products

• 666715-98-6 6-amino-3-methyl-5-[4-[[p-nitrophenoxy]sulfonyl]benzamido]uracil 
• 666715-91-9 6-amino-1,3-dimethyl-5-[4-[[p-nitrophenoxy]sulfonyl]benzamido]uracil 
• 666715-97-5 6-amino-1,3-dipropyl-5-[4-[[p-nitrophenoxy]sulfonyl]benzamido]uracil 
• 666715-99-7 6-amino-3-propyl-5-[4-[[p-nitrophenoxy]sulfonyl]benzamido]uracil 
• 666716-00-3 6-amino-3-butyl-5-[4-[[p-nitrophenoxy]sulfonyl]benzamido]uracil 
• 666715-92-0 1,3-dimethyl-8-[4-[[[p-nitrophenyl]oxy]sulfonyl]phenyl]xanthine 
• 666716-07-0 1-propyl-8-[4-[[[p-nitrophenyl]oxy]sulfonyl]phenyl]xanthine 
• 1161743-34-5 4-(6-amino-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-ylcarbamoyl)benzenesulfonic acid 4-nitrophenyl ester 
• 1161743-36-7 4-(6-amino-2,4-dioxo-3-prop-2-ynyl-1,2,3,4-tetrahydropyrimidin-5-ylcarbamoyl)benzenesulfonic acid 4-nitrophenyl ester 

Relevant articles and documents

A2B Adenosine Receptor Antagonists with Picomolar Potency

The A2B adenosine receptor (A2BAR) was proposed as a novel target for the (immuno)therapy of cancer since A2BAR blockade results in antiproliferative, antiangiogenic, antimetastatic, and immunostimulatory effects. In this study, we explored the structure-activity relationships of xanthin-8-yl-benzenesulfonamides mainly by introducing a variety of linkers and substituents attached to the sulfonamide residue. A new, convergent strategy was established, which facilitated the synthesis of the target compounds. Many of the new compounds exhibited subnanomolar affinity for the A2BAR combined with high selectivity. Functional groups were introduced, which will allow the attachment of dyes and other reporter groups. 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine (34, PSB-1901) was the most potent A2B-antagonist (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10 000-fold selectivity versus all other AR subtypes. It was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclinical studies. Computational studies predicted halogen bonding to contribute to the outstanding potency of 34.