66635-92-5 Usage
Description
(S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID), with IC50s of 0.1 and 2.7 μM for COX-1 and COX-2, respectively. It is the S-enantiomer of Ketorolac and is approximately twice as potent as the racemic mixture and 60 times more potent than (R)-ketorolac in a rat pain assay. (S)-Ketorolac is cleared more quickly from rat kidney and liver than (R)-ketorolac. Formulations containing ketorolac are used to manage postoperative pain and as an ophthalmic solution to treat ocular pain and inflammation.
Uses
Used in Pharmaceutical Industry:
(S)-Ketorolac is used as a prostaglandin biosynthesis inhibitor for its analgesic and anti-inflammatory properties. It is particularly effective in managing postoperative pain and reducing ocular pain and inflammation when used as an ophthalmic solution.
Used in Pain Management:
(S)-Ketorolac is used as an analgesic for its potent pain-relieving effects, which are approximately 60 times more potent than the (R)-enantiomer. This makes it a valuable component in formulations aimed at providing effective pain relief.
Used in Inflammation Reduction:
(S)-Ketorolac is used as an anti-inflammatory agent to reduce inflammation and associated symptoms. Its high potency compared to the (R)-enantiomer makes it a preferred choice in treatments where inflammation is a concern.
Check Digit Verification of cas no
The CAS Registry Mumber 66635-92-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,6,3 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 66635-92:
(7*6)+(6*6)+(5*6)+(4*3)+(3*5)+(2*9)+(1*2)=155
155 % 10 = 5
So 66635-92-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1
66635-92-5Relevant articles and documents
Direct coupling of pyrroles with carbonyl compounds: Short enantioselective synthesis of (S)-ketorolac
Baran, Phil S.,Richter, Jeremy M.,Lin, David W.
, p. 609 - 612 (2005)
An odd couple: The union of pyrroles and carbonyl compounds (ketones, amides, esters, lactones, lactams, see scheme) is described, and by the use of an intramolecular variant of this new method, the nonsteroidal, anti-inflammatory drug (S)-ketorolac has b
Dual Mechanoenzymatic Kinetic Resolution of (±)-Ketorolac
Juaristi, Eusebio,Pérez-Venegas, Mario,Rodríguez-Trevi?o, Agustín Mario
, (2020/02/15)
Recently, biocatalysis mediated by mechanical energy has become a convenient strategy to obtain highly valuable products following the principles of green chemistry. In particular, mechanoenzymatic techniques have allowed the isolation of chiral drugs wit
Sodium salt of phenylacetic acid compound as well as crystalline form and preparation method of sodium salt
-
, (2019/12/25)
The invention provides a sodium salt of a phenylacetic acid compound as well as a crystalline form and preparation method of the sodium salt, a pharmaceutical composition containing the sodium salt, and a preparation form and a pharmaceutical application
