66348-18-3 Usage
Description
TRIS(TRIFLUOROMETHYL)IODOGERMANE, with the chemical formula Ge(CF3)3I, is a germanium-based chemical compound that features a germanium atom connected to three trifluoromethyl groups and one iodine atom. It is recognized for its high reactivity and its role in the trifluoromethylation of organic substrates, which is crucial in the synthesis of pharmaceuticals and agrochemicals. Due to its reactive nature, it requires careful handling and storage to maintain safety.
Uses
Used in Pharmaceutical Industry:
TRIS(TRIFLUOROMETHYL)IODOGERMANE is used as a reagent for the introduction of trifluoromethyl groups into organic molecules, which is essential for the development of new pharmaceuticals. The trifluoromethyl group is known to enhance the lipophilicity and metabolic stability of drug molecules, thereby improving their pharmacokinetic properties and therapeutic efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, TRIS(TRIFLUOROMETHYL)IODOGERMANE serves as a reagent for the trifluoromethylation of organic compounds, contributing to the synthesis of novel agrochemicals with improved performance. The introduction of trifluoromethyl groups can enhance the biological activity and selectivity of agrochemicals, leading to more effective pest control and crop protection.
Used in Organic Synthesis:
TRIS(TRIFLUOROMETHYL)IODOGERMANE is utilized as a key reagent in organic synthesis for the trifluoromethylation of a wide range of organic substrates. Its ability to selectively introduce trifluoromethyl groups allows for the creation of new organic compounds with unique properties and potential applications in various fields, including materials science, medicinal chemistry, and chemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 66348-18-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,3,4 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66348-18:
(7*6)+(6*6)+(5*3)+(4*4)+(3*8)+(2*1)+(1*8)=143
143 % 10 = 3
So 66348-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C3F9GeI/c4-1(5,6)13(14,2(7,8)9)3(10,11)12
66348-18-3Relevant articles and documents
Trifluoromethyl Group 2B Compounds: Bis(trifluoromethylcadmium*Base. New, More Powerful Ligand-Exchange Reagents and Low Temperature Difluorocarbene Sources
Krause, L. J.,Morrison, J. A.
, p. 2995 - 3001 (2007/10/02)
Lewis base adducts of bis(trifluoromethyl)cadmium have been isolated from the interaction of bis(trifluoromethyl)mercury with dimethylcadmium in solvents like THF, glyme, diglyme, or pyridine.Lewis base exchange, for example, pyridine for glyme, occurs upon dissolution of the glyme adduct, (CF3)2Cd*g, g = CH3OCH2CH2OCH3, in pyridine.The (CF3)2Cd*base species are shown to be much more reactive than (CF3)2Hg since the cadmium compounds are reactive at temperatures at least 100 deg C below that required for the mercurial.At ambient temperatures ligand exchanges between SnBr4 or GeI4 and (CF3)2Cd*glyme are found to be most convenient preparations of (CF3)4Sn (66percent yield) or (CF3)4Ge (43percent yield); the formation of (CF3)3P from the reaction of PI3 also occurs, but the amounts isolated are smaller.The reaction of acyl halides with (CF3)2Cd*g proceeds at subambient temperature to yield the acyl fluoride, ca. 90percent yield, and difluorocarbene which can be trapped stereospecifically by, e.g., cis-2-butene at -30 deg C.Difluorocarbene formation occurs at temperatures at least as low as -78 deg C.
