66148-18-3 Usage
Description
NORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) is a deuterated form of (RS)-Nornicotine, a tobacco alkaloid and the major metabolite of Nicotine in the brain. It is labeled with four deuterium atoms, which makes it a useful compound for scientific research and analysis.
Uses
Used in Pharmaceutical Research:
NORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) is used as a research compound for studying the pharmacological properties and mechanisms of action of (RS)-Nornicotine. Its deuterated form allows for more accurate and reliable analysis in various experimental techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.
Used in Neuropharmacology:
NORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) is used as a tool compound in neuropharmacological research to investigate the role of (RS)-Nornicotine in the central nervous system. It helps researchers understand the activation of different nicotinic acetylcholine receptor (nAChR) subtypes and the potential therapeutic applications of (RS)-Nornicotine in treating neurological disorders.
Used in Pain Management Research:
NORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) is used as an analgesic agent in pain management research. It has been shown to exhibit significant analgesic activity, making it a valuable compound for studying the underlying mechanisms of pain relief and developing new treatments for various types of pain.
Used in Toxicology Studies:
NORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) is used in toxicology studies to evaluate the safety and potential side effects of (RS)-Nornicotine. Its deuterated form provides a stable and non-radioactive alternative to the native compound, allowing for safer and more accurate toxicological assessments.
Used in Drug Development:
NORNICOTINE-2,4,5,6-D4 (PYRIDINE-D4) is used as a lead compound in drug development for the discovery of new therapeutic agents with improved pharmacokinetic profiles and reduced toxicity compared to (RS)-Nornicotine. Its deuterated nature can help optimize the drug's stability, bioavailability, and efficacy, leading to the development of more effective and safer medications.
Check Digit Verification of cas no
The CAS Registry Mumber 66148-18-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,1,4 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66148-18:
(7*6)+(6*6)+(5*1)+(4*4)+(3*8)+(2*1)+(1*8)=133
133 % 10 = 3
So 66148-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2/i1D,3D,5D,7D
66148-18-3Relevant articles and documents
Syntheses of isotope-labeled tobacco-specific nitrosamines and their metabolites
Desai, Dhimant,Krzeminski, Jacek,El-Bayoumy, Karam,Amin, Shantu
, p. 226 - 230 (2008/12/20)
We report here on the syntheses of three deuterium-labeled tobacco-specific nitrosamines namely [2,4,5,6-d4]nitroso-nornicotine([2,4,5,6-d 4]NNN), 4-(methylnitrosamino)-1-(3-[2,4,5,6-d4]pyridyl)-1- butanone ([2,4,5,6-d4]NNK), and 4-(methyl-nitrosamino)-1-(3-[2,4,5,6- d4]pyridyl)-1-butanol ([2,4,5,6-d4]NNAL). A metabolite of NNK and myosmine, 4-hydroxy-1-(3-[2,4,5,6-d4]pyridyl)-1-butanone, was also synthesized. The synthetic strategy reported here is similar to that reported in the literature for the preparation of corresponding unlabeled compounds. The commercially available [2,4,5,6-d4]ethylnicotinate was used as starting material. During the course of these syntheses [2,4,5,6-d 4]myosmme and [2,4,5,6-d4]nornicotine were obtained as stable intermediates. These isotope-labeled compounds are useful internal standards for quantification of TSNA and their metabolites in smokers in molecular epidemiological studies. Copyright
