65961-37-7Relevant articles and documents
A Facile and Efficient Preparative Method of Methyl 2-Arylpropanoates by Treatment of Propiophenones and Their Derivatives with Iodine or Iodine chlorides
Yamauchi, Takayoshi,Hattori, Kaneaki,Nakao, Kenji,Tamaki, Kentaro
, p. 4858 - 4859 (2007/10/02)
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Process for preparing arylalkanoic acid derivatives
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, (2008/06/13)
2-Aryl-C3 to C6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. A continuous process using a Scheibel column is disclosed. The ester intermediate product is then converted to the corresponding 2-aryl-C3 - to C6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.
