654-47-7

Basic information

• Product Name: 2-FLUOROPHENYLMETHYLSULFONE
• Synonyms: 1-Fluoro-2-(methylsulphonyl)Benzene;2-Fluorophenyl phenyl sulfone;2-Fluorophenyl methyl sulfone 97%;Benzene, 1-fluoro-2-(methylsulfonyl)-
• CAS NO: 654-47-7
• Molecular Formula: C₇H₇FO₂S
• Molecular Weight: 174.1926832
• Mol File: 654-47-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 51-53°C
• Boiling Point: 304.5 °C at 760 mmHg
• Flash Point: 110℃
• Appearance: /
• Density: 0.975
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-FLUOROPHENYLMETHYLSULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPHENYLMETHYLSULFONE(654-47-7)
• EPA Substance Registry System: 2-FLUOROPHENYLMETHYLSULFONE(654-47-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 654-47-7(Hazardous Substances Data)

Usage

Description

2-FLUOROPHENYLMETHYLSULFONE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes a fluorine atom attached to a phenyl ring and a sulfonyl group connected to a methyl group. This structure endows 2-FLUOROPHENYLMETHYLSULFONE with specific reactivity and properties that make it valuable in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
2-FLUOROPHENYLMETHYLSULFONE is used as a reagent for the synthesis of thiazolyl benzamides, which are novel allosteric glucokinase activators. These activators play a significant role in the regulation of glucose metabolism and have potential applications in the treatment of type 2 diabetes and other metabolic disorders. The unique structure of 2-FLUOROPHENYLMETHYLSULFONE allows for the efficient synthesis of these therapeutically relevant compounds, making it an essential component in the development of new drugs for metabolic diseases.

InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 462-06-6 fluorobenzene 
• 124-63-0 methanesulfonyl chloride 
• 3112-85-4 methylphenylsulfonate 
• 7143-01-3 Methanesulfonic anhydride 

Downstream Products

• 27489-33-4 2-hydroxyphenyl methyl sulfone 
• 1192833-21-8 C₁₉H₁₆N₄O₃S₂ 
• 1204677-58-6 BOC-(S)-3-[(R)-(2-methanesulfonylphenoxy)phenylmethyl]pyrrolidine 
• 1188525-46-3 C₇H₆ClFO₄S₂ 
• 1147012-23-4 methyl 3-isopropoxy-5-[2-(methylsulfonyl)phenoxy]-benzoate 
• 1147012-19-8 methyl 2-bromo-5-[2-(methylsulfonyl)phenoxy]benzoate 
• 1147012-22-3 methyl 3-ethoxy-5-[2-(methylsulfonyl)phenoxy]-benzoate 
• 916488-42-1 1-[2-(methylsulfonyl)phenyl]piperazine dihydrochloride 
• 916488-41-0 4-[2-(methylsulfonyl)phenyl]piperazine-1-carbaldehyde 

Relevant articles and documents

Selective aromatic electrochemical fluorination of methyl phenyl sulfone

Electrochemical fluorination of methyl phenyl sulfone occurs exclusively at the aromatic ring to give isomeric methyl mono- and difluorophenyl sulfones and methyl 3,3,6,6-tetrafluoro-1,4-cyclohexadienyl sulfone.

Total Synergistic effect between triflic acid and bismuth(IIIr antimony(III) chlorides in catalysis of the Methanesulfonylation of Arenes

A total synergistic effect between bismuth(III) or antimony(III) chlorides and triflic acid has been observed in the Friedel-Crafts methanesulfonylation of arenes and has resulted in the development of the first efficient catalytic systems usable for the methanesulfonylation of both activated and deactivated arenes. A proposed mechanism to explain the observed effects is also discussed. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.